The effect of Fermentable, Oligosaccharides, Disaccharides, Monosaccharides, and Polyols (FODMAPs) diet on upper gastrointestinal (GI) function in patients with overlapping irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD)
Phase 1
Completed
- Conditions
- The effects of FODMAPs diet on transient lower esophageal sphincter relaxation (TLESR), intestinal gas production, and postprandial GERD and other GI symptoms in overlapping IBS-GERD patients.non-constipation irritable bowel syndrome, GERD, rice, wheat, Low FODMAPs, High FODMAPs, intestinal gas, hydrogen, gastrointestinal symptoms
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 8
Inclusion Criteria
1. 18-65 years old, 2. non-constipation type IBS patients according to the Rome III criteria, 3. typical GER (troublesome heartburn and/or regurgitation) symptoms, 4. Informed consent
Exclusion Criteria
1. Previous history of abdominal surgery, 2. pregnancy, 3. major psychological disorders, 4. history of allergy to the test meals, 5. Chronic obstructive pulmonary disease (COPD), asthma, 6. Celiac disease, gluten and wheat allergy was excluded by a serologic test (negative serum immunoglobulin A anti-tissue transglutaminase; tTG antibody) and a specific skin prick test for gluten and wheat, 7. Probiotic supplements, prokinetics, laxatives, antibiotics or medications that affect GI functions and symptoms in the preceding 4 weeks prior to the study
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The number of TLESR 2 hours after lunch ingestion High resolution esophageal manometry (HRM) catheter
- Secondary Outcome Measures
Name Time Method Hydrogen and Methane gas concentration, GI symptom scores 8 hours after breakfast ingestion Hydrogen breath test, Visual analog scale