Effects of Renal Replacement Therapy With Hemoadsoption in Patients With Sepsis

Completed

• Conditions: Sepsis

• Registration Number: NCT04533256
• Lead Sponsor: Institutul Clinic Fundeni

Brief Summary

Hemoadsorption has been demonstrated to improve clinical and paraclinical results in critically ill patients with sepsis and septic shock. The present study investigates the effects of three consecutive sessions of hemoadsorption, performed in accordance to the local protocol for treating patients with sepsis, on organ failure, severity scores and 30-days mortality. Paraclinical results and severity scores were obtained before and after the three consecutive sessions.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-07-10
• Study First Submitted: 2020-08-26
• Study First Submitted QC: 2020-08-26
• Study First Posted: 2020-08-31
• Primary Completion: 2021-07-30
• Study Completion: 2021-07-30
• Status Verified: 2021-09
• Last Update Submitted: 2021-09-03
• Last Update Posted: 2021-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• patients with sepsis or septic shock who require hemoadsorption in accordance with local guidelines

Exclusion Criteria

• unsigned informed consent
• duration of therapy under 12 hours
• death before the three consecutive sessions

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
28-days mortality	28 days after ICU admission	28-days mortality

Secondary Outcome Measures

Name	Time	Method
severity score	3 days	dynamics of SOFA score (Sequential Organ Failure Assessment) calculated as the mathematical difference in post-therapy SOFA score and pre-therapy SOFA score

Trial Locations

Locations (1)

Fundeni Clinical Institute; 🇷🇴 Bucharest, Romania