The use of aminolaevulinic acid (ALA) and photodynamic therapy (PDT) in the treatment of Barrett's oesophagus

Completed

• Conditions: Barrett's oesophagus; Digestive System

• Registration Number: ISRCTN05257682
• Lead Sponsor: HS R&D Regional Programme Register - Department of Health (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2004-01-23
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Patients with biopsy proven high grade dysplasia associated with Barrett's oesophagus who would otherwise require oesophagogastrectomy will be offered ALA-induced PDT. Two groups:
1. Patients with high grade dysplasia who will receive PDT followed by surgery if there is no response
2. Patients with low grade dysplasia who are at lower risk of carcinoma will be entered into a controlled trial and followed up by endoscopy to assess the efficacy and duration of any treatment effects.

Exclusion Criteria

Not provided at time of registration

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ablation of low grade dysplastic epithelium

Secondary Outcome Measures

Name	Time	Method
ot provided at time of registration