An Efficacy and Safety Study of Ontamalimab as Maintenance Therapy in Participants With Moderate to Severe Ulcerative Colitis
- Registration Number
- NCT03290781
- Lead Sponsor
- Shire
- Brief Summary
The purpose of this study is to evaluate the efficacy of ontamalimab as maintenance therapy treatment of remission, based on composite score of patient-reported symptoms and centrally read endoscopy, in participants with moderate to severe ulcerative colitis (UC).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 366
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Participants and/or their parent or legally authorized representative must have an understanding, ability, and willingness to fully comply with study procedures and restrictions.
-
Participants must be able to voluntarily provide written, signed, and dated (personally or via a legally authorized representative) informed consent and/or assent, as applicable, to participate in the study.
-
Participants must have completed the 12-week induction treatment period (SHP647-301 [NCT03259334] and SHP647-302 [NCT03259308]).
-
Participants must have achieved clinical response in induction study (SHP647-301 [NCT03259334] and SHP647-302 [NCT03259308]). Clinical response is defined as:
i) A decrease from the induction study (SHP647-301 [NCT03259334] and SHP647-302 [NCT03259308]) baseline in the composite score of patient reported symptoms using daily e-diary and centrally read endoscopy of at least 2 points and at least 30 percent (%), with an accompanying decrease in the sub score for rectal bleeding greater than or equal to (>=) 1 point or a sub score for rectal bleeding less than or equal to (<=) 1 OR ii) A decrease from the induction study (SHP647-301 [NCT03259334] and SHP647-302 [NCT03259308]) baseline in total Mayo score of at least 3 points and at least 30%, with an accompanying decrease in the rectal bleeding sub score of at least 1 point or an absolute rectal bleeding sub score of 0 or 1.
For eligibility assessment, clinical response will be determined based on the centrally read endoscopy performed during screening and at Week 12 of induction study (SHP647-301 [NCT03259334] and SHP647-302 [NCT03259308]).
- Participants receiving any treatment(s) for ulcerative colitis (UC) are eligible provided they have been, and are anticipated to be, on a stable dose for the designated period of time.
- Participants who had major protocol deviation(s) (as determined by the sponsor) in induction study (SHP647-301 [NCT03259334] and SHP647-302 [NCT03259308]).
- Participants who permanently discontinued investigational product because of an adverse event (AE), regardless of relatedness to investigational product, in induction study (SHP647-301 [NCT03259334] and SHP647-302 [NCT03259308]).
- Participants who are likely to require surgery for UC during the study period.
- Participants are females who became pregnant during induction study (SHP647-301 [NCT03259334] and SHP647-302 [NCT03259308]), females who are planning to become pregnant during the study period, or males or females of childbearing potential not agreeing to continue using appropriate contraception methods (that is [i.e,] highly effective methods for female and medically appropriate methods for male study participants) through the conclusion of study participation.
- Participants who do not agree to postpone donation of any organ or tissue, including male participants who are planning to bank or donate sperm and female participants who are planning to harvest or donate eggs, for the duration of the study and through 16 weeks after last dose of investigational product.
- Participants who, in the opinion of the investigator or the sponsor, will be uncooperative or unable to comply with study procedures.
- Participants who have a newly diagnosed malignancy or recurrence of malignancy (other than resected cutaneous basal cell carcinoma, squamous cell carcinoma, or carcinoma in situ of the uterine cervix that has been treated with no evidence of recurrence).
- Participants who have developed any major illness/condition or evidence of an unstable clinical condition (example [eg], renal, hepatic, hematologic, gastrointestinal (except disease under study), endocrine, cardiovascular, pulmonary, immunologic [eg, Felty's syndrome], or local active infection/infectious illness) that, in the investigator's judgment, will substantially increase the risk to the participant if he or she participates in the study.
- Participants with any other severe acute or chronic medical or psychiatric condition or laboratory or electrocardiogram (ECG) abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the participant inappropriate for entry into this study.
- Participants with known exposure to Mycobacterium tuberculosis (TB) since testing at screening in induction study (SHP647-301 [NCT03259334] and SHP647-302 [NCT03259308]) and who are without a generally accepted course of treatment.
- Participants who are investigational site staff members or relatives of those site staff members or participants who are sponsor employees directly involved in the conduct of the study.
- Participants who are participating in or plan to participate in other investigational studies (other than induction study SHP647- 301 [NCT03259334] and SHP647-302 [NCT03259308]) during study SHP647-303 [NCT03290781].
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Participants will receive 25 mg or 75 mg ontamalimab or placebo matched to ontamalimab in the induction studies (SHP647-301 \[NCT03259334\] and SHP647-302 \[NCT03259308\]) will receive placebo matched to ontamalimab as maintenance treatment subcutaneously using a prefilled syringe Q4W up to Week 52. Ontamalimab 25 mg Ontamalimab Participants will receive 25 milligram (mg) of ontamalimab or placebo and achieved a clinical response in one of the induction studies (SHP647-301 \[NCT03259334\] and SHP647-302 \[NCT03259308\]) will receive 25 mg of ontamalimab as maintenance treatment subcutaneously using a prefilled syringe once in every 4 weeks (Q4W) up to Week 52. Ontamalimab 75 mg Ontamalimab Participants will receive 75 mg of ontamalimab or placebo and achieved a clinical response in one of the induction studies (SHP647-301 \[NCT03259334\] and SHP647-302 \[NCT03259308\]) will receive 75 mg of ontamalimab as maintenance treatment subcutaneously using a prefilled syringe Q4W up to Week 52.
- Primary Outcome Measures
Name Time Method Number of Participants With Remission Based on Composite Score at Week 52 At Week 52 Remission: a composite score of participant reported symptoms using daily e-diary and centrally read endoscopy as follows: stool frequency sub-score 0 or 1 with at least a 1-point change from induction study baseline; and rectal bleeding sub-score of 0; and endoscopic sub-score 0 or 1 (modified, excludes friability). The composite score was a recommended measure consisted of Mayo score without the Physician global assessment (PGA) sub-score and ranges from 0-9 points. The Mayo score was a measure of UC disease activity ranged from 0-12 points and consisted of 4 sub-scores, each graded from 0-3 with higher scores indicating more severe disease. Sub-scores were rectal bleeding (range: 0-3, where 0= no blood \& 3=blood alone passes), stool frequency (range: 0-3, where 0= normal number of stools and 3=at least 5 stools more than normal), PGA sub-score (range: 0-3- higher score= severe disease), and an endoscopic sub-score (range: 0-3, where 0= normal/inactive disease; 3= severe disease).
- Secondary Outcome Measures
Name Time Method Number of Participants With Clinical Response Based on Composite Score at Week 52 At Week 52 Clinical response was defined as a decrease from induction study baseline in the composite score of subject reported symptoms using daily e-diary and centrally read endoscopy of at least 2 points and at least 30%, with an accompanying decrease in the sub-score for rectal bleeding \>=1 point or a sub-score for rectal bleeding \<= 1. Composite score consisted of Mayo score without the PGA sub-score and ranges from 0 to 9 points. Mayo score was a measure of UC disease activity, ranged from 0 -12 points and consisted of 4 sub-scores, each graded from 0 -3, higher scores indicating more severe disease. The rectal bleeding sub-scores ranges from 0-3, where 0= no blood \& 3=blood alone passes and centrally read endoscopic sub-score ranges from 0-3, where 0= normal/inactive disease; 3= severe disease.
Number of Participants With Sustained Endoscopic Remission at Week 52 At Week 52 Sustained endoscopic remission was defined as in endoscopic remission at Week 52 visit among participants who were in endoscopic remission at the time of baseline. Endoscopic remission was defined as a centrally read endoscopic sub-score of 0 or 1 (modified, excludes friability). The centrally read endoscopic sub-score range from 0 to 3, where 0=normal or inactive disease; 3=severe disease.
Number of Participants With Glucocorticoid-free Clinical Remission at Week 52 At Week 52 Glucocorticoid-free clinical remission was defined as clinical remission in addition to not requiring any treatment with glucocorticoids for at least 4 weeks prior to the Week 52 visit among participants using glucocorticoids at the baseline. Clinical remission was defined as stool frequency sub-score of 0 or 1 with at least a 1-point change from induction study baseline in stool frequency sub-score, and rectal bleeding sub-score of 0, at the Week 52 visit. The stool frequency sub-score ranges from 0-3, where 0= normal number of stools and 3=at least 5 stools more than normal and rectal bleeding sub-score ranges from 0-3, where 0= no blood \& 3=blood alone passes).
Number of Participants With Remission Based on Total Mayo Score at Week 52 At Week 52 Remission defined as a total mayo score of less than or equal to (\<=) 2 with no individual sub-score (stool frequency, rectal bleeding, endoscopy \[modified, excludes friability\], and physician's global assessment) exceeding 1. The total mayo score ranges from 0 to 12 points and consisted of the following 4 sub-scores, each graded from 0 to 3 with higher scores indicating more severe disease: Sub-scores were rectal bleeding (range: 0 to 3, where 0=no blood seen and 3=blood alone passes), stool frequency (range: 0 to 3, where 0=normal number of stools and 3=at least 5 stools more than normal), PGA sub-score (range: 0 to 3-higher score indicating the severe disease), and an endoscopic sub-score (range: 0 to 3, where 0=normal or inactive disease; 3=severe disease \[spontaneous bleeding, ulceration\].
Number of Participants With Clinical Remission at Week 52 At Week 52 Clinical remission was defined by stool frequency sub-score of 0 or 1 with at least a 1-point change from induction study baseline in stool frequency sub-score, and rectal bleeding sub-score of 0. Rectal bleeding was assessed on a scale from 0-3, where 0: no blood seen, 1: streaks of blood with stool less than half time, 2: obvious blood or streaks of blood with stool most of the time, and 3: blood alone passes. Stool frequency was assessed on a scale from 0-3, where 0: normal number of stools for this participant, 1: 1 to 2 stools more than normal; 2: 3 to 4 stools more than normal, and 3: 5 or more stools more than normal. Higher scores indicated more severe disease.
Number of Participants With Mucosal Healing Based on Endoscopic and Histologic Assessment at Week 52 At Week 52 Mucosal healing was defined by centrally read endoscopic sub-score 0 or 1 (modified, excludes friability) and centrally read Geboes score of \<=2. The centrally read endoscopic sub-score of mayo score ranges from 0 to 3 with higher scores indicating more severe disease. Geboes score grading system, was a validated score for evaluating histologic disease activity in UC as follows: grade 0 = structural and architectural changes; grade 1 = chronic inflammatory infiltrate; grade 2 = lamina propria neutrophils and eosinophils; grade 3 = neutrophils in the epithelium; grade 4 = crypt destruction; grade 5 = erosions or ulceration. A higher Geboes score indicates more severe disease.
Number of Participants With Clinical Remission Based on Both Rectal Bleeding and Stool Frequency Sub-scores of 0 At Week 4, 8, 12, 16, 20, 24, 28, 32, 36, 40, 44, 48 and 52 Clinical remission was defined as both rectal bleeding and stool frequency sub-scores of 0. Rectal bleeding was assessed on a scale from 0-3, where 0: no blood seen, 1: streaks of blood with stool less than half time, 2: obvious blood or streaks of blood with stool most of the time, and 3: blood alone passes. Stool frequency was assessed on a scale from 0-3, where 0: normal number of stools for this participant, 1: 1 to 2 stools more than normal, 2: 3 to 4 stools more than normal, and 3: 5 or more stools more than normal. Higher scores indicated more severe disease.
Number of Participants Who Developed Positive Antidrug Antibodies to Ontamalimab At Week 12, 24, 36 and 52 Antibody testing was conducted using an electro chemiluminescent signal method. Serum samples was analyzed for presence of antidrug antibodies to ontamalimab. Number of participants who developed positive results for ontamalimab were reported.
Number of Participants With Endoscopic Remission at Week 52 At Week 52 Endoscopic remission was defined by centrally read endoscopic sub-score 0 or 1 (modified, excludes friability). The centrally read endoscopic sub-score of mayo score ranged from 0 to 3, where 0=normal or inactive disease; 3=severe disease (spontaneous bleeding, ulceration).
Number of Participants With Glucocorticoid-free Remission at Week 52 At Week 52 Glucocorticoid-free remission was defined as remission in addition to not requiring any treatment with glucocorticoids for at least 4 weeks prior to the Week 52 visit, among participants using glucocorticoids at the baseline. Remission was defined as a composite score of participant-reported symptoms using daily e-diary and endoscopy, with stool frequency sub-score of 0 or 1 with at least a 1-point change from induction study baseline, and rectal bleeding sub-score of 0, and endoscopic sub-score of 0 or 1 (modified, excludes friability). The composite score was a recommended measure consisting of the Mayo score without the PGA sub-score and ranges from 0 to 9 points. The stool frequency sub-score, rectal bleeding sub-score and endoscopic sub-score of mayo score ranges from 0 to 3 with higher scores indicating more severe disease.
Number of Participants With Sustained Remission at Week 52 At Week 52 Sustained remission was defined as in remission at Week 52 visit, among participants who were in remission at the time of baseline. Remission was defined as a stool frequency sub-score of 0 or 1 with at least a 1-point change from induction study baseline in stool frequency sub-score and rectal bleeding sub-score of 0 and endoscopic sub-score of 0 or 1 (modified, excludes friability). Sub-scores were rectal bleeding (range: 0-3, where 0= no blood \& 3=blood alone passes), stool frequency (range: 0-3, where 0= normal number of stools and 3=at least 5 stools more than normal), and an endoscopic sub-score (range: 0-3, where 0= normal/inactive disease; 3= severe disease).
Number of Participants With Treatment Emergent Adverse Events (TEAEs) From start of study drug administration up to follow-up (Week 64) An adverse event (AE) was any untoward medical occurrence in a clinical investigation participant administered a pharmaceutical product and that does not necessarily have a causal relationship with this treatment. TEAEs are defined as AEs with start dates at the time of or following the first exposure to investigational product. Number of participants with TEAEs were reported.
Trial Locations
- Locations (395)
Arizona Digestive Health Mesa - East
🇺🇸Mesa, Arizona, United States
Advanced Research Center
🇺🇸Anaheim, California, United States
Atlanta Gastroenterology Specialists, PC
🇺🇸Atlanta, Georgia, United States
Infinite Clinical Trials
🇺🇸Atlanta, Georgia, United States
East Carolina Gastroenterology
🇺🇸Jacksonville, North Carolina, United States
DM Clinical Research - ERN - PPDS
🇺🇸Tomball, Texas, United States
Percuro Clinical Research LTD
🇨🇦Victoria, British Columbia, Canada
Toronto Digestive Disease Associates Inc
🇨🇦Toronto, Ontario, Canada
Azienda Ospedaliera Mater Domini Di Catanzaro
🇮🇹Catanzaro, Calabria, Italy
NZOZ All Medicus
🇵🇱Katowice, Poland
Hospital de São Bernardo
🇵🇹Setubal, Portugal
Care Access Research, San Pablo
🇺🇸San Pablo, California, United States
University of California San Diego
🇺🇸La Jolla, California, United States
Loretto Hospital
🇺🇸Chicago, Illinois, United States
Mayo Clinic Health System - PPDS
🇺🇸Duluth, Minnesota, United States
Kindred Medical Institute for Clinical Trials, LLC
🇺🇸Corona, California, United States
NYU Langone Long Island Clinical Research Associates
🇺🇸Lake Success, New York, United States
UMass Memorial Medical Center
🇺🇸Worcester, Massachusetts, United States
Southtowns Gastroenterology, PLLC
🇺🇸Orchard Park, New York, United States
Renaissance Research Medical Group, INC
🇺🇸Cape Coral, Florida, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
National Clinical, LLC
🇺🇸Hamtramck, Michigan, United States
Gastro Florida
🇺🇸Clearwater, Florida, United States
St Louis Center For Clinical Research
🇺🇸Saint Louis, Missouri, United States
OM Research LLC - Lancaster - ClinEdge - PPDS
🇺🇸Lancaster, California, United States
SIH Research
🇺🇸Kissimmee, Florida, United States
New York Total Medical Care PC
🇺🇸Brooklyn, New York, United States
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Liverpool Hospital
🇦🇺Liverpool, New South Wales, Australia
LKH-Universitätsklinikum Klinikum Graz
🇦🇹Graz, Steiermark, Austria
Commonwealth Clinical Studies LLC
🇺🇸Brockton, Massachusetts, United States
Ohio Clinical Research Partners LLC
🇺🇸Mentor, Ohio, United States
Hospital Privado Centro Médico de Córdoba
🇦🇷Córdoba, Argentina
Royal Adelaide Hospital
🇦🇺Adelaide, South Australia, Australia
Medical Center-1-Sevlievo EOOD
🇧🇬Sevlievo, Bulgaria
Exemplar Research, Inc. - Elkins
🇺🇸Elkins, West Virginia, United States
Fundación Favaloro
🇦🇷Buenos Aires, Argentina
Mid Atlantic Health Specialists
🇺🇸Galax, Virginia, United States
AZ Groeninge
🇧🇪Kortrijk, West-Vlaanderen, Belgium
Royal Brisbane & Women's Hospital
🇦🇺Herston, Queensland, Australia
Concord Repatriation General Hospital
🇦🇺Concord, New South Wales, Australia
Medizinische Universitat Wien (Medical University of Vienna)
🇦🇹Wien, Austria
University Multiprofile Hospital for Active Treatment Sv Ivan Rilski EAD
🇧🇬Sofia, Bulgaria
University Hospital Centre Split
ðŸ‡ðŸ‡·Split, Croatia
Clinical Hospital Centre Osijek
ðŸ‡ðŸ‡·Osijek, Croatia
Institut Klinicke A Experimentalni Mediciny
🇨🇿Praha 4, Czechia
Theageneio Anticancer Oncology Hospital of Thessaloniki
🇬🇷Thessaloniki, Greece
Euromedica - PPDS
🇬🇷Thessaloniki, Greece
Toho University Sakura Medical Center
🇯🇵Sakura, Japan
Charité - Universitätsmedizin Berlin
🇩🇪Berlin, Germany
Medical Corporation Aoyama Clinic
🇯🇵Kobe-shi, Hyôgo, Japan
Samsung Medical Center PPDS
🇰🇷Seoul, Korea, Republic of
CHA Bundang Medical Center, CHA University
🇰🇷Seongnam, Gyeonggido, Korea, Republic of
Rafik Hariri University Hospital
🇱🇧Beirut, Lebanon
Accelerium, S. de R.L. de C.V.
🇲🇽Monterrey, Mexico
VU Medisch Centrum
🇳🇱Amsterdam, Netherlands
Yonsei University Wonju Severance Christian Hospital
🇰🇷Wonju, Gang'weondo, Korea, Republic of
Auckland City Hospital
🇳🇿Grafton, Auckland, New Zealand
Fondazione Policlinico Universitario A Gemelli
🇮🇹Roma, Italy
Nihonbashi Egawa Clinic
🇯🇵Chuo-Ku, Tokyo, Japan
Bellland General Hospital
🇯🇵Sakai, Japan
Dokkyo Medical University Hospital
🇯🇵Shimotsuga-gun, Japan
Koukokukai Ebisu Clinic
🇯🇵Tokyo, Japan
Kitasato University Kitasato Institute Hospital
🇯🇵Minato-ku, Tokyo, Japan
The Catholic University of Korea, St. Vincent's Hospital
🇰🇷Suwon, Gyeonggido, Korea, Republic of
Szpital Uniwersytecki Nr 2 im. Dr Jana Biziela w Bydgoszczy
🇵🇱Bydgoszcz, Poland
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo, Japan
Phylasis Clinicas Research S. de R.L. de C.V.
🇲🇽Cuautitlán Izcalli, Mexico
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Clinica de Higado y Gastroenterologia Integral, S.C.
🇲🇽Cuernavaca, Morelos, Mexico
Seoul National University Hospital
🇰🇷Seoul, Korea, Republic of
Severance Hospital Yonsei University Health System - PPDS
🇰🇷Seoul, Korea, Republic of
Inje University Seoul Paik Hospital
🇰🇷Seoul, Korea, Republic of
Kyung Hee University Hospital
🇰🇷Seoul, Korea, Republic of
Kyungpook National University Hospital
🇰🇷Daegu, Daegu Gwang'yeogsi, Korea, Republic of
Lexmedica
🇵🇱Wroclaw, Dolnoslaskie, Poland
H-T. Centrum Medyczne Endoterapia
🇵🇱Tychy, Poland
Wellington Hospital
🇳🇿Newtown, Wellington, New Zealand
Dunedin Hospital
🇳🇿Dunedin, South Island, New Zealand
BioVirtus Centrum Medyczne
🇵🇱Jozefow, Mazowieckie, Poland
Hospital Universitario La Paz - PPDS
🇪🇸Madrid, Spain
Waikato Hospital
🇳🇿Hamilton, New Zealand
Twoja Przychodnia - Centrum Medyczne Nowa Sol
🇵🇱Nowa Sól, Poland
Hospital Universitario de Fuenlabrada
🇪🇸Fuenlabrada, Madrid, Spain
Prof. Dr. Matei Bals Institute of Infectious Diseases
🇷🇴Bucharest, Romania
Affidea Romania SRL
🇷🇴Constanta, Romania
Dr. J Breedt
🇿🇦Pretoria, Gauteng, South Africa
Hospital Universitario Virgen del Rocio - PPDS
🇪🇸Sevilla, Spain
Dr. Goldis Gastroenterology Center SRL
🇷🇴Timisoara, Romania
CLINRESCO, ARWYP Medical Suites
🇿🇦Johannesburg, Gauteng, South Africa
First St. Petersburg State Medical University n.a. I.P Pavlov
🇷🇺St. Petersburg, Russian Federation
Clinical Hospital Center Bezanijska Kosa
🇷🇸Belgrade, Serbia
Moscow Regional Research Clinical Institute Na Mfvladimirskiy
🇷🇺Moscow, Russian Federation
Hospital Universitario Juan Ramon Jimenez
🇪🇸Huelva, Spain
Istanbul Universitesi Cerrahpasa Tip Fakultesi
🇹🇷Istanbul, Turkey
Western General Hospital Edinburgh - PPDS
🇬🇧Edinburh, United Kingdom
Hospital Universitario Fundacion Jimenez Diaz
🇪🇸Madrid, Spain
CHUVI - H.U. Alvaro Cunqueiro
🇪🇸Vigo, Pontevedra, Spain
Royal Shrewsbury Hospital
🇬🇧Shrewsbury, Shropshire, United Kingdom
Communal Non-Commercial Enterprise Vinnytsia City Clinical Hospital 1
🇺🇦Vinnytsia, Ukraine
Aberdeen Royal Infirmary - PPDS
🇬🇧Aberdeen, Aberdeen City, United Kingdom
Fairfield General Hospital - PPDS
🇬🇧Lancashire, Bury, United Kingdom
Royal Gwent Hospital - PPDS
🇬🇧Newport, United Kingdom
New Cross Hospital
🇬🇧Wolverhampton, United Kingdom
Southwest Clinical Trials
🇺🇸Houston, Texas, United States
Aztec Medical Research
🇺🇸Houston, Texas, United States
BI Research Center
🇺🇸Houston, Texas, United States
Shinbeppu Hospital
🇯🇵Beppu, Ôita, Japan
Korczowski Bartosz, Gabinet Lekarski
🇵🇱Rzeszow, Poland
Cluj-Napoca Emergency Clinical County Hospital
🇷🇴Cluj-Napoca, Cluj, Romania
Centrum Zdrowia MDM
🇵🇱Warszawa, Poland
Centralny Szpital Kliniczny MSW
🇵🇱Warszawa, Poland
Hospital Senhora da Oliveira - Guimaraes, E.P.E
🇵🇹Guimarães, Portugal
Moscow Clinical Scientific Center
🇷🇺Moscow, Russian Federation
Centro Hospitalar do Algarve - Hospital de Portimao
🇵🇹Faro, Portugal
Nizhegorodskaya Regional Clinical Hospital n.a. Semashko
🇷🇺Nizhny Novgorod, Russian Federation
Gastromedica SRL
🇷🇴Iasi, Romania
Dr. Tirnaveanu Amelita Private Practice
🇷🇴Oradea, Romania
LLC Medical Center Family Medicine Clinic
🇺🇦Dnipro, Ukraine
State Institution "Institute of Gastroenterology of National Academy of Medical Sciences of Ukraine"
🇺🇦Dnipro, Ukraine
MNPE of Kharkiv Regional Council Regional Clinical Specialized Dispensary of Radiation Protection
🇺🇦Kharkiv, Ukraine
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
Unidad de Atencion Medica e Investigacion en Salud
🇲🇽Merida, Yucatán, Mexico
Asthma and Allergy Associates PC - CRN - PPDS
🇺🇸Colorado Springs, Colorado, United States
Elite Clinical Studies - Phoenix - Clinedge - PPDS
🇺🇸Phoenix, Arizona, United States
University of California San Francisco
🇺🇸San Francisco, California, United States
Hi Tech and Global Research, LLc
🇺🇸Miami, Florida, United States
Nuren Medical and Research Center
🇺🇸Miami, Florida, United States
Encompass Care
🇺🇸North Las Vegas, Nevada, United States
Veteran's Research and Education Foundation - NAVREF - PPDS
🇺🇸Oklahoma City, Oklahoma, United States
Southern Star Research Institute LLC
🇺🇸San Antonio, Texas, United States
Fondazione IRCCS Policlinico San Matteo di Pavia
🇮🇹Pavia, Italy
Alliance Clinical Research-(Vestavia Hills)
🇺🇸Poway, California, United States
Crystal Biomedical Research
🇺🇸Miami Lakes, Florida, United States
DBC Research
🇺🇸Tamarac, Florida, United States
Gastroenterology Associates of Hazard
🇺🇸Hazard, Kentucky, United States
CroNOLA, LLC.
🇺🇸Houma, Louisiana, United States
Chevy Chase Clinical Research
🇺🇸Chevy Chase, Maryland, United States
Louisiana Research Center LLC
🇺🇸Shreveport, Louisiana, United States
Advanced Biomedical Research of America
🇺🇸Las Vegas, Nevada, United States
Piedmont Healthcare
🇺🇸Statesville, North Carolina, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Inquest Clinical Research/Coastal Gastroenterology Associates, PA - TDDC - PPDS
🇺🇸Baytown, Texas, United States
Digestive Health Associates of Texas, P.A.dba DHAT Research Institute
🇺🇸Garland, Texas, United States
Biopharma Informatic Inc.
🇺🇸Houston, Texas, United States
HP Clinical Research
🇺🇸Bountiful, Utah, United States
Winchester Gastroenterology Associates
🇺🇸Winchester, Virginia, United States
CHI Franciscan Digestive Care Associates
🇺🇸Tacoma, Washington, United States
West Virginia University Hospital
🇺🇸Morgantown, West Virginia, United States
Mater Hospital Brisbane
🇦🇺South Brisbane, Queensland, Australia
St Vincents Hospital Melbourne - PPDS
🇦🇺Melbourne, Victoria, Australia
Klinikum Klagenfurt Am Woerthersee
🇦🇹Klagenfurt am Wörthersee, Austria
Salzburger Landeskliniken
🇦🇹Salzburg, Austria
Klinikum Wels-Grieskirchen GmbH
🇦🇹Wels, Austria
UZ Gent
🇧🇪Gent, Oost-Vlaanderen, Belgium
CHU Mouscron
🇧🇪Mouscron, Belgium
Clinical Center Banja Luka
🇧🇦Banja Luka, Bosnia and Herzegovina
Acibadem City Clinic University Multiprofile Hospital for Active Treatment EOOD
🇧🇬Sofia, Sofia-Grad, Bulgaria
University Multiprofile Hospital for Active Treatment Sveta Anna
🇧🇬Sofia, Sofia-Grad, Bulgaria
La Sapienza-Università di Roma-Policlinico Umberto I
🇮🇹Roma, Italy
Multiprofile Hospital for Active Treatment Eurohospital
🇧🇬Plovdiv, Bulgaria
Specialized Hospital for Active Treatment of Pneumophthisiatric Diseases Dr.D.Gramatikov- Ruse- PPDS
🇧🇬Ruse, Bulgaria
Second Multiprofile Hospital for Active Treatment Sofia
🇧🇬Sofia, Bulgaria
Medical Center Excelsior OOD - PPDS
🇧🇬Sofia, Bulgaria
Diagnostic and Consulting Center Aleksandrovska EOOD
🇧🇬Sofia, Bulgaria
University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna - ISUL EAD
🇧🇬Sofia, Bulgaria
Medical Center Convex EOOD
🇧🇬Sofia, Bulgaria
Diagnostic Consultative Centre Mladost - M OOD
🇧🇬Varna, Bulgaria
Servimed S.A.S
🇨🇴Bucaramanga, Santander, Colombia
IPS Centro Médico Julián Coronel S.A.S. - PPDS
🇨🇴Cali, Colombia
Opca Bolnica Karlovac
ðŸ‡ðŸ‡·Karlovac, Karlovacka Županija, Croatia
General County Hospital Vukovar and Croatian Veterans Hospital
ðŸ‡ðŸ‡·Vukovar, Croatia
General Hospital Zadar
ðŸ‡ðŸ‡·Zadar, Croatia
Hepato-Gastroenterologie HK, s. r. o.
🇨🇿Hradec Králové, Královéhradecký Kraj, Czechia
PreventaMed s.r.o.
🇨🇿Olomouc, Olomoucký Kraj, Czechia
ISCARE I.V.F. a.s.
🇨🇿Praha 7, Czechia
Krajska zdravotni, a.s. - Masarykova nemocnice v Usti nad Labem, o.z.
🇨🇿Usti nad Labem, Czechia
Nemocnice Pardubickeho kraje, a.s. Orlickoustecka nemocnice
🇨🇿Ústi Nad Orlici, Czechia
East Viru Central Hospital
🇪🇪Kohta-Järve, Estonia
OÜ LV Venter
🇪🇪Parnu, Estonia
West Tallinn Central Hospital
🇪🇪Tallinn, Estonia
Universitätsklinikum Ulm
🇩🇪Ulm, Baden-Württemberg, Germany
Gastro Campus Research GbR
🇩🇪Münster, Nordrhein-Westfalen, Germany
Universitatsklinikum Schleswig-Holstein
🇩🇪Kiel, Schleswig-Holstein, Germany
Universitatsklinikum Jena
🇩🇪Jena, Thüringen, Germany
Gastroenterologische Facharztpraxis am Mexikoplatz
🇩🇪Berlin-Zehlendorf, Germany
Sana Klinikum Biberach
🇩🇪Biberach an der Riss, Germany
Universitätsklinikum Frankfurt
🇩🇪Frankfurt, Germany
Asklepios Westklinikum Hamburg Ggmbh
🇩🇪Hamburg, Germany
Klinikum rechts der Isa der Technischen Universitaet Muenchen
🇩🇪Munich, Germany
Ippokrateio General Hospital of Athens
🇬🇷Athens, Attiki, Greece
University General Hospital of Patras
🇬🇷Patras, Greece
Istituto Clinico Humanitas
🇮🇹Rozzano (MI), Italy
Magyar Honvédség Egészségügyi Központ
ðŸ‡ðŸ‡ºBudapest, Hungary
Pannónia Magánorvosi Centrum Kft
ðŸ‡ðŸ‡ºBudapest, Hungary
ENDOMEDIX Kft.
ðŸ‡ðŸ‡ºBudapest, Hungary
Bekes Megyei Kozponti Korhaz
ðŸ‡ðŸ‡ºGyula, Hungary
Debreceni Egyetem Klinikai Kozpont
ðŸ‡ðŸ‡ºDebrecen, Hungary
Csongrad Megyei Dr. Bugyi Istvan Korhaz
ðŸ‡ðŸ‡ºSzentes, Hungary
Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
ðŸ‡ðŸ‡ºSzékesfehérvár, Hungary
Csolnoky Ferenc Korhaz
ðŸ‡ðŸ‡ºVeszprém, Hungary
Jávorszky Ödön Kórház
ðŸ‡ðŸ‡ºVác, Hungary
St Vincent's University Hospital
🇮🇪Dublin, Ireland
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Hadassah Medical Center - PPDS
🇮🇱Jerusalem, Israel
Galilee Medical Center
🇮🇱Nahariya, Israel
Nazareth EMMS Hospital
🇮🇱Nazareth, Israel
Tel Aviv Sourasky Medical Center PPDS
🇮🇱Tel Aviv, Israel
Ospedale Casa Sollievo Della Sofferenza IRCCS
🇮🇹San Giovanni Rotondo, Puglia, Italy
Azienda Ospedaliera Universitaria Careggi
🇮🇹Firenze, Toscana, Italy
Azienda Ospedale Università Padova - Dipartimento Salute della Donna e del Bambino
🇮🇹Padova, Veneto, Italy
IRCCS Ospedale Sacro Cuore Don Calabria
🇮🇹Negrar, Veneto, Italy
A.O.U. Maggiore della CaritÃ
🇮🇹Novara, Italy
Azienda Ospedaliera Ordine Mauriziano di Torino
🇮🇹Torino, Italy
Azienda Ospedaliera Città della Salute e della Scienza di Torino
🇮🇹Torino, Italy
Sapporo Medical University Hospital
🇯🇵Sapporo, Hokkaidô, Japan
Sagamihara Kyodo Hospital
🇯🇵Sagamihara, Kanagawa, Japan
Hyogo College of Medicine
🇯🇵Nishinomiya-shi, Hyôgo, Japan
Dokkyo Medical University Saitama Medical Center
🇯🇵Koshigaya, Saitama, Japan
Jikei University Hospital
🇯🇵Minato-ku, Tokyo, Japan
Ome Municipal General Hospital
🇯🇵Ome, Tokyo, Japan
Tokatsu Tsujinaka Hospital
🇯🇵Abiko, Japan
Kunimoto Hospital
🇯🇵Asahikawa, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino, Japan
Hakodate Koseiin Hakodate Goryoukaku Hospital
🇯🇵Hakodate, Japan
Kawabe Clinic
🇯🇵Koganei, Japan
Yuai Memorial Hospital
🇯🇵Koga, Japan
Hidaka Coloproctology Clinic
🇯🇵Kurume-shi, Japan
Nishinomiya Municipal Central Hospital
🇯🇵Nishinomiya, Japan
Ishida Clinic of IBD and Gastroenterology
🇯🇵Oita, Japan
Onomichi General Hospital
🇯🇵Onomichi, Japan
Kinshukai Infusion Clinic
🇯🇵Osaka-shi, Japan
Chiinkai Dojima General & Gastroenterology Clinic
🇯🇵Osaka, Japan
Pusan National University Hospital
🇰🇷Busan, Korea, Republic of
Asan Medical Center - PPDS
🇰🇷Seoul, Korea, Republic of
Hammoud Hospital University Medical Center
🇱🇧Saida, Lebanon
Centrum Diagnostyczno - Lecznicze Barska sp. z o.o.
🇵🇱Wloclawek, Kujawsko-pomorskie, Poland
Niepubliczny Zaklad Opieki Zdrowotnej CENTRUM MEDYCZNE Szpital Swietej Rodziny
🇵🇱Lódz, Lódzkie, Poland
Uniwersytecki Szpital Kliniczny im. Wojskowej Akademii Medycznej Centralny Szpital Weteranow
🇵🇱Lódz, Lódzkie, Poland
Uniwersytecki Szpital Kliniczny w Bialymstoku
🇵🇱Bialystok, Podlaskie, Poland
Med Gastr Sp.z.o.o Sp.k
🇵🇱Lodz, Poland
Centrum Innowacyjnych Terapii
🇵🇱Piaseczno, Poland
Clinical Research Center Spółka z Ograniczoną Odpowiedzialnością, Medic-R Spółka Komandytowa
🇵🇱Poznan, Poland
Rostov State Medical University
🇷🇺Rostov-on-Don, Russian Federation
Bayside Clinical Research - New Port Richey
🇺🇸Tampa, Florida, United States
Private Healthcare Institution Clinical Hospital RZD-Medicina of Samara city
🇷🇺Samara, Russian Federation
Smolensk Regional Clinical Hospital
🇷🇺Smolensk, Russian Federation
St. Elizabeth Municipal Clinical Hospital
🇷🇺St. Petersburg, Russian Federation
Univerzitna nemocnica Bratislava
🇸🇰Bratislava, Slovakia
Dr JP Wright
🇿🇦Claremont, Western Cape, South Africa
Hospital Universitari i Politecnic La Fe de Valencia
🇪🇸Valencia, Spain
Municipal Non-profit Enterprise of Kyiv Regional Council Kyiv Regional Clinical Hospital
🇺🇦Kyiv, Kyïv, Ukraine
Medical Center of LLC Medical Clinic Blagomed
🇺🇦Kyiv, Ukraine
Lviv Railway Clinical Hospital of branch Health Center of Joint Stock Co. Ukrainian Railway
🇺🇦Lviv, Ukraine
Medical Clinical Research Center of Medical Center LLC Health Clinic
🇺🇦Vinnytsia, Ukraine
Whipps Cross University Hospital
🇬🇧London, London, City Of, United Kingdom
North Tyneside General Hospital
🇬🇧North Shields, Northumberland, United Kingdom
Yeungnam University Hospital
🇰🇷Daegu, Korea, Republic of
Gachon University Gil Medical Center
🇰🇷Incheon, Korea, Republic of
Kyungpook National University Chilgok Hospital
🇰🇷Daegu, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Universitätsklinikum der RWTH Aachen
🇩🇪Aachen, Nordrhein-Westfalen, Germany
Uniklinik Köln
🇩🇪Köln, Nordrhein-Westfalen, Germany
Hospital Universitario de La Princesa
🇪🇸Madrid, Spain
Centro Medico Teknon - Grupo Quironsalud
🇪🇸Barcelona, Spain
VA Long Beach Healthcare System - NAVREF - PPDS
🇺🇸Long Beach, California, United States
Inland Empire Liver Foundation
🇺🇸Rialto, California, United States
Advanced Clinical Research Network
🇺🇸Coral Gables, Florida, United States
ENCORE Borland-Groover Clinical Research - ERN - PPDS
🇺🇸Jacksonville, Florida, United States
Alliance Medical Research LLC
🇺🇸Coral Springs, Florida, United States
Sanchez Clinical Research, Inc
🇺🇸Miami, Florida, United States
Gastroenterology Group of Naples
🇺🇸Naples, Florida, United States
Pharma Research International Inc
🇺🇸Naples, Florida, United States
Accel Research Sites - St. Petersburg - ERN - PPDS
🇺🇸Pinellas Park, Florida, United States
Edward Hines Jr VA Hospital - NAVREF - PPDS
🇺🇸Hines, Illinois, United States
East Coast Institute for Research, LLC
🇺🇸Saint Augustine, Florida, United States
IL Gastroenterology Group
🇺🇸Gurnee, Illinois, United States
Dupage Medical Group
🇺🇸Oakbrook Terrace, Illinois, United States
Medisphere Medical Research Center LLC
🇺🇸Evansville, Indiana, United States
Gastrointestinal Diseases, Inc Research - IACT- HyperCore - PPDS
🇺🇸Columbus, Georgia, United States
Atlanta Center For Gastroenterology PC
🇺🇸Decatur, Georgia, United States
Prestige Clinical Research
🇺🇸Franklin, Ohio, United States
Consultants For Clinical Research Inc
🇺🇸Fairfield, Ohio, United States
Veterans Research Foundation of Pittsburgh - NAVREF - PPDS
🇺🇸Pittsburgh, Pennsylvania, United States
Digestive Disease Associates
🇺🇸Wyomissing, Pennsylvania, United States
Precision Research Institute, LLC
🇺🇸Houston, Texas, United States
Northside Gastroenterology
🇺🇸Cypress, Texas, United States
BRCR Medical Center, Inc
🇺🇸Plantation, Florida, United States
Clinical Research Institute of Michigan
🇺🇸Chesterfield, Michigan, United States
Clinical Trials of SWLA, LLC
🇺🇸Lake Charles, Louisiana, United States
Atria Clinical Research - Clinedge - PPDS
🇺🇸Little Rock, Arkansas, United States
Digestive Health Center PA
🇺🇸Ocean Springs, Mississippi, United States
Sanatorio 9 de Julio SA
🇦🇷San Miguel De Tucumán, Argentina
UZ Gasthuisberg
🇧🇪Leuven, Vlaams Brabant, Belgium
Baruch Padeh Poriya Medical Center
🇮🇱Tiberias, Israel
Azienda Ospedaliera San Camillo Forlanini
🇮🇹Roma, Lazio, Italy
Weill Cornell Medical College
🇺🇸New York, New York, United States
The Alfred Hospital
🇦🇺Box Hill, Victoria, Australia
Opca bolnica Bjelovar
ðŸ‡ðŸ‡·Bjelovar, Croatia
Advanced Gastroenterology-Union City
🇺🇸Union City, Tennessee, United States
A.ö. Krankenhaus der Barmherzigen Brüder
🇦🇹St. Veit an der Glan, Kärnten, Austria
University Hospital Center Zagreb
ðŸ‡ðŸ‡·Zagreb, Grad Zagreb, Croatia
General Hospital Virovitica
ðŸ‡ðŸ‡·Virovitica, Croatia
Tolna Megyei Balassa János Kórház
ðŸ‡ðŸ‡ºSzekszard, Hungary
Aizawa Hospital
🇯🇵Matsumoto-shi, Japan
Shiga University of Medical Science Hospital
🇯🇵Otsu-Shi, Japan
Tohoku Rosai Hospital
🇯🇵Sendai, Japan
Universitätsklinikum St. Pölten
🇦🇹St. Pölten, Saint Pölten, Austria
University Multiprofile Hospital for Active Treatment - Dr. Georgi Stranski EAD
🇧🇬Pleven, Bulgaria
Hospital Pablo Tobón Uribe
🇨🇴Medellin, Antioquia, Colombia
Mohacsi Korhaz
ðŸ‡ðŸ‡ºMohacs, Hungary
Sapporo Tokushukai Hospital
🇯🇵Sapporo-shi, Japan
Aichi Medical University Hospital
🇯🇵Nagakute, Japan
Medical Corporation Shoyu-kai Fujita Gastroenterology Hospital
🇯🇵Takatsuki, Japan
Yodogawa Christian Hospital
🇯🇵Osaka, Ôsaka, Japan
Hospital of Lithuanian University of Health Sciences Kaunas Clinics
🇱🇹Kaunas, Lithuania
Vilnius University Hospital Santaros Klinikos
🇱🇹Vilnius, Lithuania
Vilnius City Clinical Hospital
🇱🇹Vilnius, Lithuania
Centro de Investigación Médica Aguascalientes
🇲🇽Aguascalientes, Mexico
Centro de Investigacion Clinica Acelerada, S.C.
🇲🇽Distrito Federal, Mexico
Instituto de Investigaciones Aplicadas a la Neurociencia A.C.
🇲🇽Durango, Mexico
NWZ, location Alkmaar
🇳🇱Alkmaar, Noord-Holland, Netherlands
Academisch Medisch Centrum Amsterdam
🇳🇱Amsterdam, Netherlands
Melita Medical
🇵🇱Wroclaw, Dolnoslaskie, Poland
Instytut Centrum Zdrowia Matki Polki
🇵🇱Lódz, Lódzkie, Poland
Krakowskie Centrum Medyczne
🇵🇱Krakow, Malopolskie, Poland
Clinical Research Institute
🇲🇽Tlalnepantla De Baz, Mexico
Investigacion Biomedica para el Desarrollo de Farmacos S.A. de C.V.
🇲🇽Zapopan, Mexico
ETZ-Elisabeth
🇳🇱Tilburg, Noord-Brabant, Netherlands
Miedzyleski Szpital Specjalistyczny w Warszawie
🇵🇱Warszawa, Mazowieckie, Poland
Szpital Zakonu Bonifratrow pw. Aniolow Strozow w Katowicach
🇵🇱Katowice, Slaskie, Poland
Centrum Medyczne Czestochowa - PRATIA - PPDS
🇵🇱Czestochowa, Poland
Centrum Medyczne Gdynia - PRATIA - PPDS
🇵🇱Gdynia, Poland
Centrum Opieki Zdrowotnej Orkan-Med Stec-Michalska Sp. J.
🇵🇱Ksawerow, Poland
Sonomed Sp. z o.o.
🇵🇱Szczecin, Poland
Hospital de Braga
🇵🇹Braga, Portugal
Colentina Clinical Hospital
🇷🇴Bucharest, Romania
Fundeni Clinical Institute
🇷🇴Bucharest, Romania
Centrul Medical Hifu Terramed Conformal S.R.L.
🇷🇴Bucuresti, Romania
Medical University Reaviz
🇷🇺Samara, Russian Federation
Leids Universitair Medisch Centrum
🇳🇱Leiden, Zuid-Holland, Netherlands
Vitamed Galaj i Cichomski sp.j.
🇵🇱Bydgoszcz, Kujawsko-pomorskie, Poland
Gastromed Kopon Zmudzinski i Wspolnicy Sp.j.Specjalistyczne Centrum Gastrologii i Endoskopii Specj
🇵🇱Torun, Kujawsko-pomorskie, Poland
Niepubliczny Zakład Opieki Zdrowotnej VIVAMED
🇵🇱Warszawa, Mazowieckie, Poland
Endoskopia Sp. z o.o.
🇵🇱Sopot, Pomorskie, Poland
Szpital Specjalistyczny sw Lukasza - Oddzial Gastroenterologii
🇵🇱Konskie, Swietokrzyskie, Poland
Twoja Przychodnia - Szczecińskie Centrum Medyczne
🇵🇱Szczecin, Zachodniopomorskie, Poland
Centrum Medyczne Pratia Bydgoszcz
🇵🇱Bydgoszcz, Poland
Centrum Medyczne A-Z Clinic Mateusz Sidor, Piotr Puc-Lekarze Spolka Partnerska
🇵🇱Krakow, Poland
Bandurskiego 98/U12
🇵🇱Szczecin, Poland
Centrum Medyczne Warszawa - PRATIA - PPDS
🇵🇱Warszawa, Poland
Samodzielny Publiczny Szpital Wojewodzki im. Papieza Jana Pawla II
🇵🇱Zamosc, Poland
Hospital da Luz
🇵🇹Lisbon, Lisboa, Portugal
Dr.Carol Davila Emergency University Central Military Hospital
🇷🇴Bucharest, Romania
Sana Monitoring SRL
🇷🇴Bucharest, Romania
Kazan State Medical University
🇷🇺Kazan, Russian Federation
Research Institute of Physiology and Basic Medicine
🇷🇺Novosibirsk, Russian Federation
Medical Company Hepatolog, LLC
🇷🇺Samara, Russian Federation
General Hospital Vrsac
🇷🇸Vrsac, Serbia
University Clinical Center Kragujevac
🇷🇸Kragujevac, Šumadijski Okrug, Serbia
Gastro LM, s.r.o.
🇸🇰Presov, Slovakia
Russian Medical Military Academy n.a. S.M. Kirov
🇷🇺Saint Petersburg, Russian Federation
Regional Consulting and Diagnostics Centre
🇷🇺Tyumen, Russian Federation
KM Management, spol. s r.o.
🇸🇰Nitra, Slovakia
Union Clinic, LLC
🇷🇺Saint Petersburg, Russian Federation
University Clinical Center Nis
🇷🇸Nis, Serbia
Mersin University Medical Faculty
🇹🇷Mersin, Turkey
Regional Municipal Non-profit Enterprise "Chernivtsi Regional Clinical Hospital"
🇺🇦Chernivtsi, Chernivets'ka Oblast, Ukraine
Communal Nonprofit Enterprise Vinnytsia Regional Clinical Hospital named after N.I. Pirogov VRC
🇺🇦Vinnytsia, Ukraine
Clinic of SI National Institute of Therapy n.a. L.T. Mala of NAMS of Ukraine
🇺🇦Kharkiv, Ukraine
Communal Non-Commercial Enterprize of Kharkiv Regional Council Regional Clinical Hospital
🇺🇦Kharkiv, Ukraine
Municipal Institution of KRC Kyiv Regional Hospital #2
🇺🇦Kyiv, Ukraine
MNPE City Hospital No. 6 of Zaporizhzhia City Council
🇺🇦Zaporizhzhia, Ukraine
SHI Regional Clinical Hospital
🇷🇺Saratov, Russian Federation
Stavropol State Medical University
🇷🇺Stavropol, Russian Federation
C.H. Regional Reina Sofia - PPDS
🇪🇸Cordoba, Córdoba, Spain
Universität Zürich
🇨ðŸ‡Zürich, Zürich (de), Switzerland
Municipal Nonprofit Enterprise CCH #2 n.a. prof. O.O. Shalimov of Kharkiv City Council
🇺🇦Kharkiv, Kharkivs'ka Oblast, Ukraine
ME Dnipropetrovsk Regional Clinical Hospital n.a. I.I Mechnykov Dnipropetrovsk Regional Council
🇺🇦Dnipro, Ukraine
Kyiv City Clinical Hospital #18
🇺🇦Kyiv, Ukraine
Municipal Non-profit Enterprise City Emergency Care Hospital of Zaporizhzhia Regional Council
🇺🇦Zaporizhzhia, Zaporiz'ka Oblast, Ukraine
Municipal Non-profit Enterprise Kherson City Clinical Hospital named after Ye.Ye. Karabelesh
🇺🇦Kherson, Ukraine
Municipal Enterprise Kryvyi Rih City Clinical Hospital #2 of Kryvyi Rih City Council
🇺🇦Kryvyi Rih, Ukraine
Treatment and Diagnostic Center "Healthy and Happy" of LLC "Healthy and Happy"
🇺🇦Kyiv, Ukraine
Municipal Nonprofit Enterprise Lviv Clinical Emergency Care Hospital
🇺🇦Lviv, Ukraine
Municipal Non-profit Enterprise Odessa Regional Clinical Hospital of Odessa Regional Council
🇺🇦Odesa, Ukraine
MNPE Central City Clinical Hospital of Uzhhorod City Council
🇺🇦Uzhhorod, Ukraine
Omega Research Consultants LLC - Clinedge - PPDS
🇺🇸Orlando, Florida, United States
University of Michigan
🇺🇸Ann Arbor, Michigan, United States
JM Research S.C
🇲🇽Cuernavaca, Morelos, Mexico
Azienda Ospedaliero Universitaria Di Bologna - Policlinico S Orsola Malpighi
🇮🇹Bologna, Emilia-Romagna, Italy
United Medical Doctors
🇺🇸Murrieta, California, United States
Facey Medical Foundation
🇺🇸Mission Hills, California, United States
Laporte County Institute For Clinical Research
🇺🇸Michigan City, Indiana, United States
Azienda Ospedaliero Universitaria Di Modena Policlinico
🇮🇹Modena, Emilia-Romagna, Italy