Comparison of the Postoperative Analgesic Effects of ITM and Bi-level ESPB in Liver Transplantation Donors

Not Applicable

Recruiting

• Conditions: Liver Transplantation; Pain Management

• Registration Number: NCT07123740
• Lead Sponsor: Ankara Etlik City Hospital

Brief Summary

Liver transplantation is a life-saving procedure for patients with end-stage liver disease, and postoperative pain management is critical for optimizing donor recovery and overall outcomes. Poorly controlled pain following donor hepatectomy may reduce quality of life, delay mobilization, and contribute to the development of chronic pain syndromes.

Regional anesthesia techniques, such as intrathecal morphine and erector spinae plane block, have been utilized to enhance postoperative analgesia and reduce perioperative opioid requirements, potentially minimizing opioid-related adverse effects.

In this study, we aimed to compare the postoperative analgesic efficacy of intrathecal morphine and Bi-level erector spinae plane block in living liver donors.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-08
• Study First Submitted: 2025-08-08
• Study First Submitted QC: 2025-08-08
• Study First Posted: 2025-08-14
• Study Start: 2025-08-18
• Last Update Submitted: 2025-08-18
• Last Update Posted: 2025-08-19
• Primary Completion: 2026-07-10
• Study Completion: 2026-07-24

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Patients aged 18-65 years
• American Society of Anesthesiologists (ASA) score I-II
• Body Mass Index (BMI) between 18-30 kg/m2

Exclusion Criteria

• Patients under 18 and over 65 years of age
• ASA score III and above
• Patients with a history of bleeding diathesis
• BMI below 18 or above 30 kg/m2

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Pain Scores	On the operation day	Pain will be assessed at rest and while coughing using the visual analog scale on a scale from 0 (no pain) to 10 (worst pain). Pain assessment will be done at 0st, 1st, 2nd,4th, 12th, and 24th hours after surgery.

Secondary Outcome Measures

Name	Time	Method
Intraoperative opioid consumption	Intraoperative period	Remifentanil consumption for intraoperative period will be recorded
Postoperative Opioid Consumption	On the operation day	Opioid consumption for 24 hours will be recorded

Trial Locations

Locations (1)

Ankara Etlik City Hospital; 🇹🇷 Altındağ, Ankara, Turkey

Ankara Etlik City Hospital

🇹🇷Altındağ, Ankara, Turkey

Atakan Sezgi, M.D.

Contact

00905323327000

kansezgi@gmail.com

Jülide Ergil, Professor

Contact

00905323469216

julideergil@hotmail.com