The physiologic study of high-flow nasal oxygen cannula in patients with chronic obstructive pulmonary disease with acute exacerbation requiring ventilator support

Not Applicable

Completed

• Conditions: Patients with chronic ostructive pulmonary disease presented with acute exacerbation and requiring non- invasive ventilation; Chronic obstructive pulmonary disease; High- flow nasal oxygen cannula; Non- Work of breathing

• Registration Number: TCTR20160902001
• Lead Sponsor: Faculty of Medicine Siriraj Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-09-02
• Study Completion: 2017-02-28
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

1. Age 40-85 years old
2. Patients who was diagnosed COPD classified by GOLD criteria (post-bronchodilator FEV1/FVC < 70%)
3. Acute exacerbation of COPD with indication for NIV use as follows
- Acute respiratory acidosis (pH/=45 mmHg)
- Respiratory rate > 24 breaths/min
- Accessory muscles use or abdominal paradox breathing

Exclusion Criteria

1. pH < 7.25
2. Severe hypoxemia
3. Alteration of consciousness and uncooperative (GCS < 8)
4. Hemodynamic instability or serious cardiac problem e.g hypotension, malignant arrhythmia, myocardial ischemia
5. Facial abnormality or recent facial/upper GI tract surgery
6. Uncontrolled airway or upper GI bleeding
7. Contraindication for insertion of esophageal balloon catheter - ulcer, varices, tumor, recent esophageal/gastric surgery, bleeding diathesis or allergy to lidocaine

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient's work of breathing every 15 minutes Esophageal pressure-time product

Secondary Outcome Measures

Name	Time	Method
Respiratory variables every 15 minutes Respiratory rate, oxygen saturation, transcutaneous CO2 monitoring,Hemodynamic variables every 15 minutes Blood pressure, heart rate,Dyspnea every 15 minutes Dyspnea visual analog scale