Clinical Evaluation of Leech Therapy & Qurs-e-mafasil in the Treatment of Knee Osteoarthritis

Phase 2

Completed

• Conditions: Health Condition 1: null- Knee osteoarthritis

• Registration Number: CTRI/2012/04/002564
• Lead Sponsor: Jamia Hamdard

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Individuals > 40 yrs, either sex

Diagnosed as OA of the knee of at least 6 months duration fulfilling American College of Rheumatology criteria

Knee pain VAS- pain after walking 1,524 cm (50 feet) in a flat surface >30 mm and <90 mm

Kellgren-Lawrence Radiographic Grading Scale of Osteoarthritis of the Tibiofemoral Joint Grade 1â?? 3

Patients who were willing to discontinue all NSAIDs or other analgesic medication taken for any condition

Patients who had given their written informed consent & agreed to follow the protocol voluntarily

Exclusion Criteria

Pregnancy and Lactation

Anemia ( <10 g% Hb) and Bleeding disorders

Diabetes mellitus

Patients who were on steroid drug therapy

History of surgery of the joint involved, Tidal lavage or arthroscopy of either knee within the past 12 months

Hypersensitivity/ allergy to food &/ drug or leech

Intra-articular (IA) corticosteroid injection of either knee within a 3 month interval immediately prior to baseline screening

Acute medical or surgical conditions which could affect the outcome of the study such as cardiac, renal, hepatic diseases.

Patients who were using anti-coagulants (coumadin, heparin, aspirin >325 mg per day).

Patients were not willing to be randomized

Ongoing use of prohibited medication including NSAID, other oral analgesic, muscle relaxant, or low-dose antidepressant for any chronic pain management

Concomitant skin disease at the application site

History of alcohol or Drug abuse, excessive smoking (more than 10 cigarettes/day)

Established/ diagnosed neurological or psychiatric disorders

Study & Design

• Study Type: Interventional
• Study Design: Not specified