Assessment Of Vitamin D Role In The Pathogenesis Of Asthma In Vitamin D Resistent Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Metacholine Challenge Test
研究概览
简要总结
Research Title: Evaluation of airway reactivity, allergy and inflammatory mediators in exhaled breath condensate in vitamin D resistant rickets.
Aim: To assess the effect of absence of vitamin D receptors on airway reactivity, allergy and inflammatory mediators in exhaled breath condensate in a prospective study evaluating patients with vitamin D resistant rickets and in healthy controls.
Sample size: 40 participants in the two groups. Primary end point: Airway reactivity as assessed by methacholine challenge test.
Secondary outcome parameters: All other parameters are the secondary end points.
详细描述
Research Title: Evaluation of airway reactivity, allergy and inflammatory mediators in exhaled breath condensate in vitamin D resistant rickets.
Introduction: Vitamin D seems to play a role in allergic and asthmatic reactions. Vitamin D resistant rickets patients lack vitamin D receptors and cannot absorb vitamin D.
Aim: To assess the effect of absence of vitamin D receptors on airway reactivity, allergy and inflammatory mediators in exhaled breath condensate.
Design: Prospective study evaluating these parameters in patients with vitamin D resistant rickets and in healthy controls.
Participant selection: The study group will consist of vitamin D resistant rickets patients followed and treated at the Pediatric Endocrinology Department at our hospital. The study group will be compared to an age- and sex-matched healthy control group that had a negative methacholine challenge test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 3 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Vitamin D Resistent Rickets
- •Age between 3 - 40 years
排除标准
- •Any Chronic Lung Disease
- •Febrile Illness in last 2 weeks
- •Inhaled Corticosteroids over the past 2 weeks
- •Bronchodilators over the past 24 hours
- •Participation in any other clinical studies over the past 4 weeks
结局指标
主要结局
Metacholine Challenge Test
时间窗: participants will be followed for the duration of hospital visit, an average of 3 hours
As assessed by methacholine challenge test with determination of PC20.
次要结局
- IgE(participants will be followed for the duration of hospital visit, an average of 3 hours)
- CBC(participants will be followed for the duration of hospital visit, an average of 3 hours)
- Fractional Exhaled NO(participants will be followed for the duration of hospital visit, an average of 3 hours)
- skin tests for inhaled allergens(participants will be followed for the duration of hospital visit, an average of 3 hours)
- Inhaled breath condensate(participants will be followed for the duration of hospital visit, an average of 3 hours)
- C reactive protein(participants will be followed for the duration of hospital visit, an average of 3 hours)
- 25 OH vitamin D3(participants will be followed for the duration of hospital visit, an average of 3 hours)