The Relationship Between Vitamin D Levels, Inflammatory Parameters and Disease Severity of COVID-19 Infection: A Retrospective Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- neutrophil count
研究概览
简要总结
Vitamin D deficiency increases the susceptibility to respiratory virus infections and the severity of infections. Inflammation plays a key role in pathogenesis in COVID19 while identifying clinical course and prognosis COVID19.The aim of this study was to determine the relationship between 25OH vitamin D levels, inflammatory laboratory parameters of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), C-reactive protein (CRP) levels and disease severity of COVID19 infection.
详细描述
In this retrospective study 300 patients diagnosed with COVID19 were included. According to clinical classification of cases with COVID19 the patients were divided into three groups; mild (Group1), moderate (Group2) and severe/critical (Group3). The 25OH vitamin D values below 20 ng/ml were defined as deficiency, 21-29 ng/ml were defined as insufficiency, and 30 ng/ml and above were defined as normal. Patients' age, gender, comorbid diseases and laboratory values were recorded
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 16 Years 至 97 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The study included 300 polymerase chain reaction (PCR) test positive patients and whose 25-OH vitamin D levels were measured in the last 6 months
排除标准
- •Patients with COVID-19 whose 25-OH vitamin D levels were not measured in the last 6 months before the COVID-19 diagnosis were excluded from the study
结局指标
主要结局
neutrophil count
时间窗: 1 day
laboratory measurement in unit of x103/uL
neutrophil to lymphocyte ratio
时间窗: 1 day
laboratory measurement in unit of %
hemoglobin count
时间窗: 1 day
laboratory measurement in unit of g/dl
25-OH vitamin D
时间窗: 1 day
laboratory measurement in unit of ng/ml
lymphocyte count
时间窗: 1 day
x103/uL
White blood cell count
时间窗: 1 day
laboratory measurement in unit of x103/uL
platelet count
时间窗: 1 day
laboratory measurement in unit of x103/uL
C-reactive protein levels
时间窗: 1 day
laboratory measurement in unit of mg/dL
neutrophil ratio
时间窗: 1 day
laboratory measurement in unit of %
lymphocyte ratio
时间窗: 1 day
laboratory measurement in unit of %
platelet to lymphocyte ratio
时间窗: 1 day
laboratory measurement in unit of %
次要结局
未报告次要终点