Butyrate: effect of oral administration in patients with mild hypertension - BEAM study

Academisch Medisch Centrum0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年4月15日

适应症

试验速览

暂无简介。

•- Age between 40 and 65 years
•- For females: postmenopausal status
•- Caucasian
•- Mild hypertension (defined as systolic blood pressure range 140-159 mmHg
•and/or diastolic blood pressure range 90-100 mmHg) without antihypertensive
•medication OR use of 1 antihypertensive drug due to hypertension and willing to
•temporarily stop this medication
•- Body mass index (BMI) lower than 27 kg/m2

•- Insufficient knowledge of the Dutch language
•- Use of betablockers
•- Known secondary causes of hypertension such as renal artery stenosis, adrenal
•or thyroid disease
•- History of cardiovascular disease: angina pectoris, myocardial infarction,
•cerebrovascular accident, transient ischemic attack, peripheral artery disease,
•heart failure.
•- History of diabetes mellitus
•- Current smoking
•- Antibiotics usage within three months before inclusion
•- Having a severe disease of the digestive tract, such as celiac disease,
•Crohn*s disease, active ulcerative colitis or short bowel syndrome.
•- Impaired renal function, defined as an estimated glomerular filtration rate
•(eGFR) lower than 60 ml/min/1,73m2 using the CKD-EPI formula within a period of
•two years before the screening visit. Participants without an available lab
•result on renal function will not be included.

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