Butyrate: Effect of Oral Administration in patients with Mild Hypertension

Amsterdam UMC0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

•Age between 40 and 65 years
•- For females: postmenopausal status
•- Caucasian
•- Mild hypertension (defined as systolic blood pressure between 140 and 159 mmHg and/or diastolic blood pressure between 90 and 99 mmHg) OR use of 1 antihypertensive drug due to hypertension and willing to temporarily stop this medication during the study
•- BMI lower than 27 kg/m2

•- Use of betablockers
•- Known secondary causes of hypertension such as renal artery stenosis, adrenal or thyroid disease
•- History of cardiovascular disease: angina pectoris, myocardial infarction, cerebrovascular accident, transient ischemic attack, peripheral artery disease, heart failure.
•- History of diabetes mellitus
•- Current smoking
•- Antibiotics usage within three months before inclusion
•- Having a severe disease of the digestive tract, such as celiac disease, Crohn’s disease, active
•ulcerative colitis or short bowel syndrome.
•- Impaired renal function, defined as an estimated glomerular filtration rate (eGFR) lower than 60
•ml/min/1,73m2 using the CKD-EPI formula

发起方

Amsterdam UMC