Invloed van ultrafijn stof op de gezondheid van gezonde vrijwilligers:Klinische studie ultrafijn stof rondom Schiphol
- Conditions
- ung functionHeart functionInflammationOxidative stress
- Registration Number
- NL-OMON27988
- Lead Sponsor
- Academic Medical Center Amsterdam in collaboration with the National Institute for Public Health and the Environment (RIVM)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
•Healthy subjects between 18 and 35 years of age
•No clinically significant findings during physical examination
Exclusion Criteria
•History of pulmonary or cardiovascular events/diseases
•History of hay fever
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary endpoints are exhaled Nitric Oxide (FeNO) for inflammation and blood pressure for the cardiovascular effects
- Secondary Outcome Measures
Name Time Method Secondary outcome parameters are:<br /><br>-Lung function (Flow/Volume)<br /><br>-Oxygen saturation<br /><br>-Heart rate<br /><br>-ECG<br /><br>-SpiroNose measurement<br /><br>-Oxidative stress markers in urine collected shortly before and 24 hours after on site exposure<br /><br>-Molecular markers as measured in peripheral blood<br>