Hypopituitarism in patients after subarachnoid hemorrhage: screening and treatment

Recruiting

Conditions: hemorrhagic stroke
subarachnoid hemorrhage
10021112
10007963

Registration Number: NL-OMON39410

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 180

Inclusion Criteria

Subarachnoid hemorrhage
Age >= 18 years
Discharge from ICU
Signed and dated informed consent document;Controls will be patient-matched on age (+/- 5 years) and gender.

Exclusion Criteria

Any hypothalamic/pituitary disease diagnosed prior to SAH.
History of cranial irradiation
Prior significant trauma capitis
Another significant intracranial lesion (apart from SAH or its sequellae)
Any other medical or psychiatric condition or laboratory abnormality that may impose a risk for participation in the study or interfere with the interpretation of the study (according to the judgment of the investigators).;Exclusion criteria healthy controls: individuals with deficits which affect physical fitness or activity (eg amputations, hip/knee prosthesis, cognitive problems), individuals at risk for health issues because of maximal testing (according to the Par Q checklist).

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>the incidence and potential riskfactors of hypopituitarism in patients after a<br /><br>SAB<br /><br><br /><br>potential base line SAB riskfactors: hydrocephalus, extravasated blood, delayed<br /><br>cerebral ischemia, glasgow coma scale in relation with hypopituitarism.<br /><br><br /><br></p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1) Incidence and potential riskfactors of growthhormone defeciency in patients<br /><br>after SAB.<br /><br>2) Value of Ghrelin test for GHD shortly after SAH<br /><br>3) Difference in physical functioning in patients with hypopituitarism and the<br /><br>control group, identified by different specific questionnaires.<br /><br>4) Difference in quality of life in patients with hypopituitarism and the<br /><br>control group, identified by different specific questionnaires.<br /><br><br /><br>5) Difference in level of everyday physical activity and physical funcitoning<br /><br>(max. oxygen consumption and muscle strength) post SAH and healthy controls.</p><br>