NCT03917212已完成不适用
Non-invasive Measurement of Energy Metabolism in Patients With Primary and Secondary Mitochondrial Diseases
German Diabetes Center2 个研究点 分布在 1 个国家目标入组 57 人开始时间: 2012年3月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 57
- 试验地点
- 2
- 主要终点
- Hepatic and skeletal muscle energy metabolism
研究概览
简要总结
Energy metabolism and insulin sensitivity were assessed in a case-control study in patients with branched-chain organic acidemias.
详细描述
Children and adults with branched-chain organic acidemias and matched healthy humans underwent deep metabolic phenotyping using non-invasive magnetic resonance spectroscopy, oral glucose tolerance tests and measurements of leucocyte respirometry in order to assess changes in energy metabolism and insulin sensitivity.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 5 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •known branched-chain organic acidemia diagnosed by enzymatic or genetic test
- •age>5 years
排除标准
- •acute inflammatory conditions with fever, cold symptoms, gastro-intestinal infection within the last 24 hours
- •contraindications for an oral glucose tolerance test such as fasting blood glucose >126 mg/dl, severe chronic gastrointestinal conditions, allergy against black currant
- •contraindications for magnetic resonance tomography (MRT) such as claustrophobia, metallic implants which are not MRT compatible
结局指标
主要结局
Hepatic and skeletal muscle energy metabolism
时间窗: At baseline
Hepatic and skeletal muscle energy metabolism assessed by magnetic resonance spectroscopy
次要结局
- Insulin sensitivity(At baseline)
研究者
研究点 (2)
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