Analgesic Efficacy of Liposomal Bupivacaine in Total Knee Arthroplasty
Overview
- Phase
- Phase 4
- Intervention
- Liposomal bupivacaine
- Conditions
- Pain, Postoperative
- Sponsor
- Miller Orthopedic Specialists
- Locations
- 1
- Primary Endpoint
- Mean visual analog scale (VAS) pain scores
- Status
- Withdrawn
- Last Updated
- 10 years ago
Overview
Brief Summary
Liposomal bupivacaine is a novel local anesthetic designed for prolonged pain relief. Despite its long-acting analgesic potential, liposomal bupivacaine is significantly more expensive than other local anesthetic alternatives. The primary aim of this investigation is to examine whether or not liposomal bupivacaine provides superior pain relief or clinically significant opioid-sparing effects versus a control to justify its cost.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients undergoing a primary unilateral total knee arthroplasty by the PI of the trial
Exclusion Criteria
- •Patients with a sensitivity to marcaine
- •Pregnant or lactating women
- •Non-English speaking individuals
Arms & Interventions
Liposomal bupivacaine
Periarticular infiltration of 20cc of liposomal bupivacaine with 20cc of normal saline administered prior to cementation of knee implants
Intervention: Liposomal bupivacaine
bupivacaine HCl, morphine, epinephrine, methylprednisolone
Periarticular infiltration of 24c of bupivacaine HCl, 0.8cc morphine, 0.3cc epinephrine, and 1cc of methylprednisolone administered prior to cementation of knee implants
Intervention: bupivacaine HCl, morphine, epinephrine, methylprednisolone
Outcomes
Primary Outcomes
Mean visual analog scale (VAS) pain scores
Time Frame: Post-operative day 2
Self-reported pain scores from 0=no pain to 10=severe pain
Pain assessment phone call
Time Frame: Post-operative day 3
Subjects will be called on post-operative day three by one of the investigators of the study. Subjects will be asked to rate their current pain level from 1 to 10 and to rate their worst pain level from 1 to 10 that day.
Secondary Outcomes
- Complications(Complications will be followed for the duration of patients' hospital stay, an expected average of 2-3 days.)