Detection of Transplanted Heart Rejection by Blood Cell Gene Expression: a Novel Concept of Personalized Approach to Heart Transplantation Management
Not Applicable
- Conditions
- Post-cardiac transplantation allograft rejection management. (Determining the clinical validity of a novel method for early detection of transplant organ rejection).Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system
- Registration Number
- ACTRN12611000008921
- Lead Sponsor
- Professor Igor Konstantinov
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
10 consecutive children aged 5-18 years undergoing heart transplantation and follow up clinical management at the Royal Children's Hospital, Melbourne.
Exclusion Criteria
Cardiac transplantation under age 5 and non-cardiac transplantation.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ongtitudinal changes in personalized gene expression pattern (Oligonucleotide Array changes) in peripheral blood with onset of rejection.[Baseline blood sample at heart transplantation, then at 4-6 week (approx monthly) endomyocardial biopsy during 1st year after transplantation (9 biopsies). (10 timepoint measures total).]
- Secondary Outcome Measures
Name Time Method il[Nil]