Brainstem Grey Matter and Cerebral Autoregulation in Migraine With Aura : a MRI and Transcranial Doppler.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 试验地点
- 1
- 主要终点
- Correlation between the density of the pontine grey matter evaluated with resonance magnetic imaging, and cerebral autoregulation measured with Transcranial Doppler in migraine with aura patients and controls.
研究概览
简要总结
Migraine with aura (MA) is an independent risk factor for stroke and is associated with silent brain infracts and T2 white matter hyperintensities on MRI. Previous studies using Transcranial Doppler (TCD) have shown an impairment of cerebral autoregulation in MA patients. Studies with positron emission tomography have demonstrated an activation of brain stem areas during migraine attack. An increased density of brain stem grey matter as measured on MRI with voxel based morphometry (VBM) has been found in MA patients. As brain arteries and arterioles are innervated by ascending tracts from aminergic brainstem nuclei, th study hypothesize a negative correlation between the density of brainstem nuclei and the efficiency of cerebral autoregulation in MA patients compared with controls.
Brainstem grey matter density will be studied with a MRI Philips 3 Tesla with a 32-channel antenna and voxel-based morphometry (VBM) cerebral autoregulation will be measured in the time domain using Transcranial Doppler (TCD) and the Mx method.
MA patients will be studied in a headache-free period. MRI and Transcranial Doppler (TCD) are non-invasive technics and will be performed on the same day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 30 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Migraine with aura patients : fulfilling the International Classification of Headache Disorders-3 beta criteria of MA
- •Control group : Gender- and age-matched subjects without history of migraine with or without aura or any other headache
排除标准
- •History of illness or injury of central or peripherical nervous system
- •Previous history of a disease potentially impairing cerebral autoregulation (diabetes, sleep apnea syndrome, uncontrolled hypertension, cardiac arrhythmia, hearth failure, carotid stenosis)
- •Contraindications related to MRI
- •Absence of temporal acoustic window
- •Pregnancy
结局指标
主要结局
Correlation between the density of the pontine grey matter evaluated with resonance magnetic imaging, and cerebral autoregulation measured with Transcranial Doppler in migraine with aura patients and controls.
时间窗: 30 days after the pre-inclusion visit
Resonance magnetic imaging use voxel base morphometry and Transcranial doppler use the coefficient mx calculation.
次要结局
- Relation between baroreflex sensitivity and cerebral autoregulation with Transcranial Doppler.(30 days after pre-inclusion visit)
- Comparison of cerebral autoregulation between migraine with aura patients and controls with Transcranial Doppler(30 days after pre-inclusion visit)
- Comparison of cerebrovascular reactivity to carbon dioxide between migraine with aura patients and controls with Transcranial Doppler(30 days after pre-inclusion visit)
- Association between grey matter density and morphological abnormalities on resonance magnetic imaging(30 days after pre-inclusion visit)
- Comparison of baroreflex sensitivity between migraine with aura patients and controls with Transcranial Doppler(30 days after pre-inclusion visit)
- Association between cerebral autoregulation and morphological abnormalities on magnetic resonance imaging(30 days after pre-inclusion visit)
- Comparison of brainstem grey matter density between migraine with aura patients and controls with magnetic resonance imaging(30 days after pre-inclusion visit)
- Comparison of morphological abnormalities between migraine with aura patients and controls with resonance magnetic imaging.(30 days after pre-inclusion visit)