Comparative evaluation of intraoperative use of two intravenous fluids(Normal Saline alone versus Normal Saline and Ringers Lactate administered alternatively as maintenance IV fluid in patients undergoing elective neurosurgery
Phase 4
- Conditions
- Health Condition 1: 4- Measurement and Monitoring
- Registration Number
- CTRI/2024/07/069745
- Lead Sponsor
- Vijayanagar Institute Of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1.Patients undergoing elective brain surgeries
2.ASA physical status grade 1 and 2
3 patients age group between 18 -60
4.Patients with preoperative GCS morethan or equal to 13
5.BMI less than or equal to 30
Exclusion Criteria
1.Patients with pre exixting renal failure (Defined ASD serum creatinine more than 2)
2.Patients with electrolyte imbalance
3.Patients who are already receiving mannitol
4.Patients having Diabetes Mellitus
5.Patients with harmone secreting tumors
6.Patients on steroids for longer durations
7.Intraoperative blood loss more than 1000ml
8.Prolonged surgeries(duration exceeding 6 hrs)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Preoperative and postoperative calculated serum osmolarity at defined intervalsTimepoint: 1.On morning of surgery <br/ ><br>2.6 hours after surgery <br/ ><br>3.On first post operative day at 9 AM
- Secondary Outcome Measures
Name Time Method 1.Preoperative & post operative serum electrolytes at defined intervals <br/ ><br>2.Preoperative & postoperative blood sugars at defined intervals <br/ ><br>3.Preoperative & post operative glasgow coma scale <br/ ><br>4.Brain relaxation score as assessed by neurosurgeons <br/ ><br>5.Total volume of IV fluids administered in 1st six hours of surgery <br/ ><br>6. Intraoperative blood loss <br/ ><br>7.Duration of surgeryTimepoint: 1.On morning of surgery <br/ ><br>2.6 hours after initiation of surgery <br/ ><br>3.On first post operative day at 9AM