Metformin as RenoProtector in Non-Diabetic Patients With Progressive Chronic Kidney Disease (CKD Stages 2, 3A and 3B): a Multi-centre, Practice-oriented, Repurposing, Double-blind, Placebo-controlled, Randomized Clinical Trial
试验速览
- 阶段
- 3 期
- 状态
- 进行中（未招募）
- 入组人数
- 290
- 试验地点
- 19
- 主要终点
- Reaching a 30% decline of eGFR
研究概览
简要总结
A multi-center, practice-oriented, repurposing, double-blinded, placebo-controlled, randomized clinical trial. The RenoMet trial is repurposing an already approved agent (Metformin , Glucophage SR ) in a new indication (renoprotection ) in a new class of patients (chronic kidney disease patients CKD 2, 3A, 3B and including patients with renal transplant for more than 3 years).
详细描述
The intervention consists in the treatment of patients with progressive kidney disease and blindly randomized to the treatment group with metformin as medication, added to their usual treatment. Metformin is a well-known and cheap medication used for many years and still used as main treatment of type 2 diabetes. In our study, this 'old' product will be used for a 'new' indication, slowing down the progression of CKD. After randomization in the participating renal care clinic, patients in the intervention group will be treated with metformin at a dose of 1000 mg/day (2x500mg) in the evening during 30 months (Metformin - Glucophage SR (Merck KGaA)). During the first month of the trial a dose of 1x500mg will be used in order to avoid as much as possible some well-known mainly gastrointestinal side effects of metformin treatment At each visit during the study period, the metformin medication will be hand over to the patient in a HDPE bottle, closed with a MEMS cap (Medication Event Monitoring System). The MEMS a cap that registers the time and date of each opening (presumed intake of the medication in the bottle).
Patients blindly randomized to the control group will receive placebo treatment (2 tablets per day) also in a MEMS device and will continue to receive usual care. Control patients will have the same data collection.
Follow-up of patients during the entire study period will be the responsibility of the treating nephrologist in the renal care clinic. All patients will have a baseline data collection at study entry (demographics, comorbidities, concomitant medication, clinical parameters, lab results). During the study period of 30 months patients will have follow-up visits at their renal care clinic every four months with collection of follow-up data (concomitant medication, clinical parameters, routine lab results and drug related problems). Extra blood and urine samples will be collected for a centralized second determination of serum creatinine and proteinuria.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (≥18 years) of both gender
- •Seen on a regular base in one of the participating outpatient clinics of renal care with a previous consultation within the last year
- •Having a chronic kidney disease (including having a transplant kidney for more than 3 years) with:
- •a CKD stage 2, 3A or 3B (i.e. with estimated glomerular filtration rate (eGFR) between 30 and 70 ml/min/1.73m2) at the time of the baseline visit
- •showing a decline of eGFR between 3.0 and 20.0 ml/min/year determined using at least three determinations of eGFR (CKD-Epi formula) whereby the oldest one should be from more than 1 year ago and the most recent will be the one of the baseline visit. For transplant patients the decline will be based on serum creatinine values determined during the preceding 24 months. For all other patients, the decline will be based on values determined within the last five years
排除标准
- •Illiteracy: patients not knowing how to read or write
- •Patients not able to communicate in Dutch or French
- •Patients with mental deterioration, incapable to give informed consent and to understand the safety instructions of the study (at the discretion of the treating nephrologist)
- •Patients with one of the following clinical problems:
- •Patients with nephrotic syndrome
- •Patients showing a fast decline of renal function (more than 20 ml/min/year) during the preceding five years
- •Diabetes mellitus (any type: 1, 2, Maturity Onset Diabetes of the Young (MODY), New Onset Diabetes After Transplantation (NODAT)) confirmed by a glycemia level >125 mg/dl (7.0 mmol/L) after a fasting time of 8 hours
- •Patients with a renal transplantation for less than 3 years
- •Patients with multi-organ transplantation
- •History of other solid organ transplantations
- •Chronic obstructive pulmonary disease (COPD) stage Gold IV (Oxygene-dependency)
- •Congestive heart failure (NYHA stage IV)
- •Inflammatory bowel disease (IBD)
- •Hepatic insufficiency or cirrhosis, acute alcohol intoxication or alcoholism (> 20 glasses of alcoholic beverages per week)
- •History of metabolic diseases (e.g. mitochondrial encephalomyopathy (MELAS), lactic acidosis, stroke-like episodes, etc...)
- •Pregnancy and/or lactating women at the time of recruitment and during the study period
- •Patient with prior use of metformin within the past 12 months (e.g. glucose intolerance, polycystic ovary syndrome, etc...) or with other study medication taken within the framework of another clinical trial
- •Patients showing elevated blood lactate level(s) at the time of recruitment (i.e. a confirmed lactate level ≥ 2.5 mmol/L at baseline and a confirmed lactate level ≥ 2.5 mmol/L after 4 weeks (±1 week)).
- •Patients showing a confirmed (after 3 months) serum bicarbonate level < 22 mmol/L (or < 20 mmol/L if delay of more than 1 hour between sampling and determination)
- •Hypersensitivity to metformin or to any of the excipients listed in section 6.1 of the Glucophage SR SmPC (see Attachment A5 Glucophage SR SmPC)
- •One of the following diseases during the previous 6 months: myocardial infarction, shock, acute problems of decompensated heart failure or respiratory failure.
研究组 & 干预措施
Metformin treatment group
干预措施: Metformin Hydrochloride (Drug)
Placebo control group
干预措施: Placebo Oral Tablet (Drug)
结局指标
主要结局
Reaching a 30% decline of eGFR
时间窗: Period of 30 months
Values of serum creatinine obtained from local determination will be used for the calculation of eGFR.
次要结局
- Mortality rate during the investigation period(Period of 30 months)
- Percentage of transplant patients with graft loss(Period of 30 months)
- Evolution of proteinuria(Difference between baseline and study end)
- Evolution of the renal function(Period of 30 months)
- Evolution of hypertension(Difference between baseline and study end)
- Hospitalization during the investigation period(Period of 30 months)
- Percentage of patients developing end-stage renal disease(Period of 30 months)
- Frequency of Major Adverse Cardiovascular Events(Period of 30 months)
- (Serious) Adverse drug events(Period of 30 months)
- Evolution of Quality of life(Period of 30 months)
研究者
Prof Dr. Marc De Broe
Prof Dr.
Universiteit Antwerpen