The Influence of Hip Replacement on Lower Extremity Hemodynamics in Crowe IV Hip Dysplasia Patient

Not Applicable

• Conditions: Hip Dysplasia
• Interventions: Procedure: total hip replacement with no osteotomy; Procedure: total hip replacement with subtrochanteral osteotomy

• Registration Number: NCT04157842
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

Explore the influence of hip replacement on lower extremity hemodynamics in Crowe Ⅳ hip dysplasia patient.

Detailed Description

Changes of limb length after total hip replacement is common, especially for Crowe Ⅳ hip dysplasia patient. Such change potentially increases tension of vessel and influence lower extremity hemodynamics. Till now, little is known in this area.

Study Timeline

• Status Verified: 2019-10
• Study First Submitted: 2019-10-23
• Study Start: 2019-11-01
• Study First Submitted QC: 2019-11-06
• Last Update Submitted: 2019-11-06
• Study First Posted: 2019-11-08
• Last Update Posted: 2019-11-08
• Primary Completion: 2021-11-01
• Study Completion: 2023-11-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Unilateral Crow IV hip dysplasia;
• Bilateral Crow IV hip dysplasia without osteoarthritis on the other side

Exclusion Criteria

• Patients with serious medical disease;
• Patients with lower extremity vascular disease; 3. Patients with severe mental illness.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
total hip replacement with no osteotomy	total hip replacement with no osteotomy	no osteotomy is applied during total hip replacement.
total hip replacement with subtrochanteral osteotomy	total hip replacement with subtrochanteral osteotomy	subtrochanteral osteotomy is applied during total hip replacement

Primary Outcome Measures

Name	Time	Method
Radiographic Results	1 week, 12 weeks, 24 weeks and 1 year after the surgery.	change of Radiographic Results from 1 week after surger to 1 year after surgery
Lower Limb Arterial CT Angiography	preoperative, 1 week, 12 weeks after the surgery.	change of vascular diameter and vascular cross-sectional from baseline(preoperative) to 1 year after surgery baseline(preoperative) to 12 weeks after surgery.
Blood Viscosity	preoperative, 1 week, 6 weeks, 12 weeks, 24 weeks and 1 year after the surgery.	change of blood viscosity from baseline(preoperative) to 1 year after surgery.
Vascular Ultrasound Examination	preoperative, 1 week, 6 weeks, 12 weeks, 24 weeks and 1 year after the surgery.	change of systolic peak velocity, end-diastolic velocity, pulsation index, resistance index and blood flow from baseline(preoperative) to 1 year after surgery.
Hip Harris Score	preoperative, 1 week, 6 weeks, 12 weeks, 24 weeks and 1 year after the surgery.	change of hip harris score scale from baseline(preoperative) to 1 year after surgery.
Leg Length Change	preoperative, 1 week, 6 weeks, 12 weeks, 24 weeks and 1 year after the surgery.	change of Leg Length from baseline(preoperative) to 1 year after surgery.