Lifestyle Modifications and the Progression of Chronic Kidney Disease

Not Applicable

Completed

• Conditions: Patients With Stage 2-4 Chronic Kidney Disease
• Interventions: Behavioral: Exercise training; Behavioral: Diet modification

• Registration Number: NCT01179906
• Lead Sponsor: Springfield College

Brief Summary

Aerobic training has been shown to favorably alter several of the known risk factors for coronary artery disease including hypertension, dyslipidemia, obesity, and diabetes (1). It seems logical that if these risk factors were aggressively controlled in patients with chronic kidney disease (CKD) by implementing lifestyle changes (e.g., diet and exercise training) to support the pharmacologic interventions that are necessary for the control of the disease, then the rate of progression of the disease may be altered. However, to date, there is no clear research evidence to support this hypothesis. Therefore the aims of the proposed study are:

1. To test the hypothesis that lifestyle interventions (i.e., dietary modification and regular, long-term aerobic exercise training) will favorably alter the natural progression of CKD in a sample of patients compared to a control group who will receive the current standard care.

2. To explore possible mechanisms that could contribute to the observed changes.

Detailed Description

Not available

Study Timeline

• Status Verified: 2006-01
• Study Start: 2006-01
• Primary Completion: 2009-02
• Study Completion: 2009-02
• Study First Submitted: 2010-08-10
• Study First Submitted QC: 2010-08-10
• Last Update Submitted: 2010-08-10
• Study First Posted: 2010-08-11
• Last Update Posted: 2010-08-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Stages 2-4 CKD

Exclusion Criteria

• CAD
• MI

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Lifestyle intervention-exercise & diet	Exercise training	Subjects trained for 48 weeks with a personal trainer
Lifestyle intervention-exercise & diet	Diet modification	Subjects trained for 48 weeks with a personal trainer

Primary Outcome Measures

Name	Time	Method
Glomerular filtration rate (GFR)	48 weeks	GFR was estimated using the MDRD equation, creatinine clearance, urea clearance

Secondary Outcome Measures

Name	Time	Method
24 hour urine protein output	48 weeks	urine protein output is measured before and after 48 weeks of the training program

Trial Locations

Locations (1)

Springfield College; 🇺🇸 Springfield, Massachusetts, United States