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Clinical Trials/NCT01209637
NCT01209637
Completed
Not Applicable

Impact of Intensive Exercise Training Compared to Inactive Controls on Coronary Collateral Circulation and Plaque Composition in Patients With Significant Stable Coronary Artery Disease

University of Leipzig1 site in 1 country60 target enrollmentMarch 2010
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ConditionsStable Coronary Artery Disease

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Stable Coronary Artery Disease
Sponsor
University of Leipzig
Enrollment
60
Locations
1
Primary Endpoint
coronary collateral blod flow
Status
Completed
Last Updated
9 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.

There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.

Registry
clinicaltrials.gov
Start Date
March 2010
End Date
December 2012
Last Updated
9 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
University of Leipzig
Responsible Party
Principal Investigator
Principal Investigator

Sven Möbius-Winkler

PI

University of Leipzig

Eligibility Criteria

Inclusion Criteria

  • •stable CAD
  • •min.1 coronary artery stenosis \>50%
  • •patient is symptomatic ( CCS 1-3)or has documented myocardial ischemia during stress test
  • •angina threshold \>75 Watt
  • •informed consent

Exclusion Criteria

  • •Age \<18 oder \>75
  • •akut coronary syndrome within 2 weeks
  • •LV-EF \< 40 %
  • •significant valve diseases
  • •reduced patient compliance
  • •muscular disorder
  • •bronchial asthma or COLD stadium III and IV

Outcomes

Primary Outcomes

coronary collateral blod flow

Time Frame: 4 weeks

Secondary Outcomes

  • plaque composition within the coronary artery(4 weeks)
  • MACCE(4 week, 6 months, 12 months)
  • atherosclerosis parameter within the laboratory(4 weeks, 3, 6, 12 months)

Study Sites (1)

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