Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable CAD
- Conditions
- Stable Coronary Artery Disease
- Registration Number
- NCT01209637
- Lead Sponsor
- University of Leipzig
- Brief Summary
Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.
There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
- stable CAD
- min.1 coronary artery stenosis >50%
- patient is symptomatic ( CCS 1-3)or has documented myocardial ischemia during stress test
- angina threshold >75 Watt
- informed consent
- Age <18 oder >75
- akut coronary syndrome within 2 weeks
- LV-EF < 40 %
- significant valve diseases
- reduced patient compliance
- muscular disorder
- bronchial asthma or COLD stadium III and IV
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method coronary collateral blod flow 4 weeks
- Secondary Outcome Measures
Name Time Method plaque composition within the coronary artery 4 weeks plaque composition measured by virtual histology intravascular ultrasound
MACCE 4 week, 6 months, 12 months major cardiovascular events (death, myocardial infarction, stroke, TIA, coronary revascularisation, hospitalisation)
atherosclerosis parameter within the laboratory 4 weeks, 3, 6, 12 months e.g. wie hs-CRP, HDL, LDL, ges. Cholesterin, Triglyceride, Zytokine, Adipokine, Endocannaboide
Trial Locations
- Locations (1)
Heart Center Leipzig- University Leipzig
🇩🇪Leipzig, Germany
Heart Center Leipzig- University Leipzig🇩🇪Leipzig, Germany