Effects of Exercise Training on Cardiovascular Health in Middle-aged Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Platelet function
研究概览
简要总结
The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 57 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Premenopausal (45-53 years) OR postmenopausal 50-57 years
- •BMI> 18.5 and <30
- •Sedentary (no regular physical activity the last 2 years)
- •Plasma measurements
- •Premenopausal: estradiol> 0.20 nmol/l, Follicle stimulating hormone < 22 IU/l and progesterone >2.5 nmol/l
- •Postmenopausal: estradiol < 0.20 nmol/l, Follicle stimulating hormone > 22 IU/l and progesterone 0.3-2.5 nmol/l
排除标准
- •Excessive alcohol intake
- •Regular medication including hormone replacement treatment
- •Chronic disease
研究组 & 干预措施
Premenopausal women
The Premenopausal women are randomized to exercise by spinning (cycle)
干预措施: Spinning (Behavioral)
Postmenopausal women
The Postmenopausal women are randomized to exercise by spinning (cycle)
干预措施: Spinning (Behavioral)
结局指标
主要结局
Platelet function
时间窗: Baseline comparison and changes from baseline to 3 months
Platelet aggregation assay of whole blood and platelet rich plasma
Leg vascular function
时间窗: Baseline comparison and changes from baseline to 3 months
Measurements of leg blood flow by ultrasound doppler during exercise and during femoral arterial infusion of vasodilators
Cardiac structure and function
时间窗: Baseline comparison and changes from baseline to 3 months
Magnetic resonance imaging and transthoracic echocardiography
次要结局
- Expression of proteins in muscle samples(Baseline comparison and changes from baseline to 3 months)
- Genomic profile in blood samples(Baseline comparison and changes from baseline to 3 months)
- Gene expression of proteins in muscle samples(Baseline comparison and changes from baseline to 3 months)
- Insulin sensitivity and glycaemic control(Baseline comparison and changes from baseline to 3 months)
- Arterial blood pressure(Baseline comparison and changes from baseline to 3 months)
- Maximal aerobic effect(Baseline comparison and changes from baseline to 3 months)
- Health related parameters in blood(Baseline comparison and changes from baseline to 3 months)
研究者
Ylva Hellsten
Professor
University of Copenhagen