NCT02135575
Completed
Not Applicable
Effects of Exercise Training on Cardiovascular Health in Middle-aged Women
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Menopause
- Sponsor
- University of Copenhagen
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- Platelet function
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The hypothesis of the present study is that physical training can oppose detrimental changes in cardiovascular and metabolic health associated with estrogen loss after menopause.
Investigators
Ylva Hellsten
Professor
University of Copenhagen
Eligibility Criteria
Inclusion Criteria
- •Premenopausal (45-53 years) OR postmenopausal 50-57 years
- •BMI\> 18.5 and \<30
- •Sedentary (no regular physical activity the last 2 years)
- •Plasma measurements
- •Premenopausal: estradiol\> 0.20 nmol/l, Follicle stimulating hormone \< 22 IU/l and progesterone \>2.5 nmol/l
- •Postmenopausal: estradiol \< 0.20 nmol/l, Follicle stimulating hormone \> 22 IU/l and progesterone 0.3-2.5 nmol/l
Exclusion Criteria
- •Excessive alcohol intake
- •Regular medication including hormone replacement treatment
- •Chronic disease
Outcomes
Primary Outcomes
Platelet function
Time Frame: Baseline comparison and changes from baseline to 3 months
Platelet aggregation assay of whole blood and platelet rich plasma
Leg vascular function
Time Frame: Baseline comparison and changes from baseline to 3 months
Measurements of leg blood flow by ultrasound doppler during exercise and during femoral arterial infusion of vasodilators
Cardiac structure and function
Time Frame: Baseline comparison and changes from baseline to 3 months
Magnetic resonance imaging and transthoracic echocardiography
Secondary Outcomes
- Expression of proteins in muscle samples(Baseline comparison and changes from baseline to 3 months)
- Genomic profile in blood samples(Baseline comparison and changes from baseline to 3 months)
- Gene expression of proteins in muscle samples(Baseline comparison and changes from baseline to 3 months)
- Insulin sensitivity and glycaemic control(Baseline comparison and changes from baseline to 3 months)
- Arterial blood pressure(Baseline comparison and changes from baseline to 3 months)
- Maximal aerobic effect(Baseline comparison and changes from baseline to 3 months)
- Health related parameters in blood(Baseline comparison and changes from baseline to 3 months)
Study Sites (1)
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