The Effect of Exercise Training on Cardiac Structure and Function
Overview
- Phase
- Phase 1
- Intervention
- Not specified
- Conditions
- Myocardial Infarction
- Sponsor
- Gaia Hospital
- Enrollment
- 200
- Locations
- 1
- Primary Endpoint
- Myocardial early diastolic velocity at mitral annulus by tissue Doppler (E' velocity)
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Exercise training, as part of cardiac rehabilitation, is effective in improving functional capacity and quality of life in patients with coronary artery disease. Other cardiovascular and non-cardiovascular benefits have been reported, namely in glucose metabolism, skeletal muscle function, oxidative stress, vascular function, pulmonary circulation, ischaemia-reperfusion lesion and ventricular remodelling.
However, the benefit of exercise training on systolic and diastolic function is controversial especially after acute myocardial infarction where no longitudinal study has evaluated diastolic function using modern echocardiographic parameters.
The hypothesis is that a structured program of exercise training can improve systolic and diastolic function in patients after myocardial infarction.
Investigators
Ricardo Fontes Carvalho
MD, PhD
Gaia Hospital
Eligibility Criteria
Inclusion Criteria
- •Patients one month after myocardial infarction
- •Older 18 years
Exclusion Criteria
- •Age above 75 years,
- •Inability to exercise,
- •Hemodinamically significant valvular disease,
- •Moderate to severe chronic lung disease (vital capacity and/or forced expiratory volume in 1 s \<80% of age-dependent predicted value),
- •Atrial fibrillation
- •Exercise induced myocardial ischemia
- •Anaemia (haemoglobin \<12 g/dl).
Outcomes
Primary Outcomes
Myocardial early diastolic velocity at mitral annulus by tissue Doppler (E' velocity)
Time Frame: 4 months
Determined by echocardiography; results in cm/s
Secondary Outcomes
- Ratio between early diastolic filling velocity from mitral inflow and myocardial early diastolic velocity at mitral annulus by tissue Doppler (E/E' ratio)(4 months)
- Myocardial systolic velocity at mitral annulus by tissue Doppler (S' velocity)(4 months)
- Left ventriclular ejection fraction(4 months)