Randomized, Controlled Study to Investigate the Effect of Neuromuscular Electrical Stimulation (NMES) on Muscle Metabolism of Abdominal Surgical Patients

Not Applicable

Completed

• Conditions: Muscular Atrophy

• Registration Number: NCT00635440
• Lead Sponsor: Medical University of Vienna

Brief Summary

Skeletal muscle atrophy is associated with catabolic conditions such as major surgical interventions and leads to reduced muscle strength, increased clinical complications and prolonged convalescence. Several studies revealed immobilisation as a major stimulus for muscle wasting in severely ill patients. This study investigates the potency of neuromuscular electrical stimulation on skeletal muscle growth factors and degradation processes in major abdominal surgery patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-12
• Study First Submitted: 2008-02-25
• Status Verified: 2008-03
• Study First Submitted QC: 2008-03-12
• Last Update Submitted: 2008-03-12
• Study First Posted: 2008-03-13
• Last Update Posted: 2008-03-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

• intended for major abdominal surgery
• more than 18 years old

Exclusion Criteria

• neuromuscular diseases
• immobility before surgery
• arterial occlusive disease Fontaine stadium IV
• clinical or laboratory signs of inflammation or sepsis
• cachexia
• diseases of the musculoskeletal systems contraindicating electrical stimulation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
mRNA level of IGF-1Ea

Secondary Outcome Measures

Name	Time	Method
mRNA level of MGF, total RNA content, total protein content, ubiquitin conjugated proteins, proteasome activity

Trial Locations

Locations (1)

Institute of Physical Medicine and Rehabilitation, Social Medical Centre South; 🇦🇹 Vienna, Austria