Multicenter Phase II study of Stereotactic Ablative Radiotherapy for Hepatocellular Carcinoma =5 cm
- Conditions
- Neoplasms
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 54
1. Male or female patients =18 years of age
2. Intitially diagnosed or recurrent hepatocellular carcinoma (HCC)
3. Unresectable HCC
4. Cirrhotic status of Child Pugh class A or B7
5. Eastern Cooerative Oncology Group performance status 0 or 1
6. single or sum of multiple tumor =5 cm
7. HCC with 3 cm apart from gastrointestinal tract
8. The volume of uninvolved must be at least 1000 ml
9. Incomplete response after trans-arterial chemo-embolization of 1-5
10. A single lesion or multiple lesions including portal vein tumor thrombosis included in radiation field with one or consecutive sesseions of SBRT
11. No evidence of an uncontrolled lesion at any other site
12. No evidence of complications of liver cirrhosis
13. No evidence of uncontrolled inter-current illness
14. Patient or gaurdian must be able to provide verbal and written informed consent
1. Patient with previous history of abdominal radiation
2. Direc invasion to esophagus, stomach or colon by HCC
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ocal control rate
- Secondary Outcome Measures
Name Time Method Overall survival rate;Progression free survival rate;Intrahepatic recurrence free survival rate;treatment related toxicity