Effects of branched-chain amino acids supplementation on skeletal muscle mass and glucose and lipid metabolism in elderly patients with type 2 diabetes: a randomized controlled study - BCAA supplementation in elderly patients with type 2 diabetes

Skeletal muscle mass and HbA1c, which were primary endpoints, did not change over time or differ between groups. However, knee extension muscle strength was significantly increased in the soy protein group and showed a tendency to increase in the BCAA group. Homeostasis model assessment for insulin resistance did not significantly change during the trial. Depressive symptoms were significantly improved in the BCAA group but the difference between groups was not significant.