Effects of calcium on gut hormone secretion in healthy participants

Not Applicable

Recruiting

• Conditions: Healthy human gastrointestinal physiology; Healthy human bone turnover physiology; Diet and Nutrition - Obesity; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function; Metabolic and Endocrine - Normal metabolism and endocrine development and function; Musculoskeletal - Normal musculoskeletal and cartilage development and function

• Registration Number: ACTRN12624000543583
• Lead Sponsor: Christine Feinle-Bisset

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-04-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Healthy
Lean weight (BMI 19-25 kg/m2)

Exclusion Criteria

Each participant will be questioned prior to the study to exclude:
• significant GI symptoms, disease or surgery
• use of prescribed or non-prescribed medications (including vitamins and herbal supplements) which may affect energy metabolism, GI function, body weight or appetite (e.g. domperidone, cisapride, anticholinergic drugs (e.g. atropine), metoclopramide, erythromycin, hyoscine, orlistat, green tea extracts, Astragalus, St Johns Wort etc.)
• lactose intolerance/other food allergy(ies)
• current gallbladder or pancreatic disease
• cardiovascular or respiratory diseases
• individuals with low ferritin levels (females <15 ng/mL, males <30 ng/mL), or who have donated blood in the 12 weeks prior to taking part in the study
• any other illnesses as assessed by the investigator (including chronic illnesses not explicitly listed above)
• high performance athletes
• current intake of > 2 standard drinks on > 5 days per week
• current smokers of tobacco (cigarettes, cigars, pipes, sheesha, chewing, vaping etc.)
• recreational drug use, e.g marijuana
• current intake of any illicit substance
• vegetarians
• inability to tolerate nasoduodenal tube
• inability to comprehend study protocol
• restrained eaters (score >12 on the 3-factor eating questionnaire)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Energy intake at a buffet meal[Each food item contained in the buffet meal will be weighed before and after being offered to the participants and energy intake will be calculated using commercially available software (Foodworks 8.0, Xyris Software, Highgate Hill, QLD, Australia). At t=75 min, participants will be presented with a standardised, buffet-style meal, to assess energy intake. The meal comprises 4 slices (~120 g) of whole-meal bread, 4 slices (~120 g) of white bread, 100 g sliced ham, 100 g sliced chicken, 85 g sliced cheddar cheese, 100 g lettuce, 100 g sliced tomato, 100 g sliced cucumber, 22 g mayonnaise, 20 g margarine, 1 apple (~170 g), 1 banana (~190 g), 175 g strawberry yogurt, 100 g chocolate custard, 120 g fruit salad, 375 mL iced coffee, 300 mL orange juice, and 600 mL water. The meal has a total energy content of ~2300 kcal (~27% fat, ~52% carbohydrate, and ~21% protein) and weight of ~2924 g.]