ACTRN12617000552381
Terminated
未知
Impact of Exercise Intervention on the Phenome (Metabolism and Predictive Complications) in Well Characterised Pre-diabetes and New Onset Type 2 diabetes Cohorts in China and Australia.
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- The University of Sydney
- Enrollment
- 162
- Status
- Terminated
- Last Updated
- 4 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •BMI greater than or equal to 25 kg/m2 (Non\-Asian participants) or BMI greater than or equal to 23 kg/m2 (Asian participants)
- •\- Willing to undertake, and have no contraindications to, exercise testing and a program involving high intensity interval training program, resistance training or stretching
- •\- Willing to give written informed consent
- •\- Adequate understanding of national language
- •\- Access to either phone or internet (this is necessary when being contacted by the instructors throughout the duration of the trial)
- •\- Maximum weight of 140kg (equivalent MRI habitus limit)
- •\- No change in medication or dose for the previous three months
- •\- 90 participants at each site will be recruited from each of three glucose groups as defined by any one of the ADA criteria. That is Type 2 Diabetes Mellitus \- HbA1c greater than or equal to 6\.5%, Fasting Plasma Glucose (FPG) greater than or equal to 7\.0 mmol/L, 2h post\-Oral Glucose Tolerance Test Plasma Glucose (2hOGTT) greater than or equal to 11\.1 mmol/L; Pre\-diabetes \- one occasion of any of the following in a participants medical history: HBA1c greater than or equal to 5\.7% but less than 6\.5%, FPG greater than or equal to 5\.6 mmol/L but less than 7\.0 mmol/L, 2hOGTT greater than or equal to 7\.8 mmol/L but less than 11\.1 mmol/L; Normal Glucose Profile \- HbA1c less than 5\.7%; FPG less than 5\.6%; 2hOGTT less than 5\.6 mmol/L.
Exclusion Criteria
- •\- Untreated dense insensate peripheral neuropathy that contraindicates exercise testing and training (as assessed by medical assessment)
- •\- Significant cardiovascular disease including current angina; myocardial infarction or stroke within the past 6 months; heart failure; symptomatic peripheral vascular disease
- •\- Active foot ulcer
- •\- Musculoskeletal condition affecting ability to undertake exercise testing and training
- •\- Self\-reported average weekly intake of alcohol \>140g per week
- •\- Abnormalities noted by medical officer based on the resting ECG suggestive of unrecognised myocardial ischaemia: q waves, or ST wave depression.
- •\- Self\-reported currently completing \>75 min/week high intensity exercise or \>150 min/week moderate intensity exercise.
- •\- Pregnancy, lactation or plans to become pregnant in the next 2 years.
- •\- Claustrophobia or ferrous metal implants/devices which contraindicate MRI scan.
- •\- Thiazolidinedione medication
Outcomes
Primary Outcomes
Not specified
Similar Trials
Recruiting
Not Applicable
Effects of physical activity intervention using an activity monitor on energy compensation and healthoncommunicable diseasesJPRN-UMIN000047348akamura Gakuen University16
Completed
Not Applicable
Effect of Physical Exercise in older adults with Pulmonary Disease from ManizalesChronic Obstructive Pulmonary Disease (COPD)RBR-9wwp8kpniversidad Autónoma de Manizales
Completed
Not Applicable
The effect of the motion exercise program on the quality of life in prostate cancer survivorsProstate Cancer Survivors.Malignant neoplasm of prostateIRCT20180113038347N1Deputy of Research of Tehran University of Medical Sciences80
Not yet recruiting
Phase 2
Effect of Exercise Program on Physical Activity, Depression and Quality of Life in Diabetic Nephropathy PatientsHealth Condition 1: E112- Type 2 diabetes mellitus with kidney complicationsCTRI/2024/05/067594itte Institute of Physiotherapy
Completed
Not Applicable
The effects of exercise on experimentally induced pain-pressure threshold; a randomised repeated measure study in healthy participants.Persistent painhealthy participantspersistent painpain thresholdhigh intensity exerciseTCTR20161107001Teesside University30