Prenatal iodine nutrition and child attention deficit-hyperactivity disorder

Not Applicable

Completed

• Conditions: Mental and Behavioural Disorders; Child ADHD diagnosis and maternally reported child ADHD symptoms at age 8 years

• Registration Number: ISRCTN41848933
• Lead Sponsor: The Research Council of Norway

Brief Summary

2017 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29137191 results 2016 Results article in https://pubmed.ncbi.nlm.nih.gov/27063603/ (added 23/08/2022)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-09-14
• Study Completion: 2017-12-31
• Last Update Posted: 5 September 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 77164

Inclusion Criteria

1. Pregnant women in their first trimester recruited from all over Norway during the years 1999 to 2008 and asked to answer questionnaires (in Norwegian) at regular intervals during pregnancy and after birth
2. To be included in the current study mothers had to have responded to a general questionnaire around gestational week (GW) 17, and a food frequency questionnaire (FFQ) around GW 22
3. Only singleton pregnancies
4. Only participants with information on all covariates were included in the analysis because of the large sample size and low rates of missing values
5. Pregnant women at any age were allowed to participate

Exclusion Criteria

1. Multiple pregnancies
2. Maternal use of thyroid medication in pregnancy
3. Missing information on important covariates
4. Children registered as dead or emigrated by Jan 2016
5. FFQs with more than 3 blank pages
6. Calculated energy intakes <4.5 MJ or >20 MJ

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> 1. Registered child ADHD diagnosis in the Norwegian Patient Registry (NPR) by Dec. 2015. From 2008, all government-owned and government-financed hospitals and outpatient clinics mandatorily report individual level diagnoses defined in the tenth revision of the International Classification of Disease (ICD-10) to the NPR in order to receive financial reimbursement. Using individual personal identification numbers, diagnostic information from NPR was linked to MoBa. Thus all MoBa children registered with an ICD-10-diagnosis of hyperkinetic disorder (HKD coded as F90.0, F90.1, F90.8, or F90.9) between 2008 and 2015 were identified and regarded as having ADHD<br> 2. Child ADHD symptoms assessed in the 8 year questionnaire from MoBa on a 4-point Likert scale (never/rarely, sometimes, often, or very often) covering inattention problems (9 items) and hyperactivity/impulsivity (9 items) from the ADHD Rating Scale<br>

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures