Research on Excessive Iodine Status in Pregnancy
- Conditions
- Thyroid Dysfunction, AntepartumExcessive Iodine StatusPregnancy RelatedNeonatal Disorder
- Interventions
- Other: Dietary iodine intake restriction
- Registration Number
- NCT03422406
- Lead Sponsor
- Peking Union Medical College Hospital
- Brief Summary
To explore main cause and health impact of iodine excess during pregnancy, we performed iodine evaluation for 390 consecutive pregnant women from January 1st, 2016 to December 31st, 2016. Among them, 18 women (4.62%) with apparently elevated urinary iodine concentration (UIC) were enrolled onto this study for subsequent follow-up. History of high iodine exposure was collected from all participants. Parameters about iodine status were monitors until termination of pregnancy, and dietary iodine intake condition and thyroid function were also evaluated.
- Detailed Description
A prospective follow-up was arranged for the 18 pregnant women with excessive iodine status. History of iodine exposure (including hysterosalpingography (HSG) using an oil-soluble iodinated contrast medium, examination by computed tomography scan with contrast, administration of amiodarone, history of receiving radioiodine therapy, etc.) was collected from all participants. Evaluation of dietary iodine intake was performed through a 72-hour dietary recall.The serum iodine concentration (SIC) and urinary iodine concentration (UIC) were monitored continuously in the whole course of pregnancy. All subjects with excessive iodine load were recommended by nutritionists to have their dietary iodine intake restricted, and resume iodine-containing supplements and foods until the UIC\<250 μg/L and SIC≤90 μg/L. After delivery, maternal colostrum iodine concentration and neonatal iodine status (including neonatal UIC, condition of congenital hypothyroidism screening tests, and thyroid physical examination) were also assessed.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 18
- Pregnant women with apparently elevated urinary iodine concentration (UIC ≥250μg/L) and serum iodine concentration (SIC>90μg/L) were enrolled in this study.
- Subject who did not sign the informed consent or whose clinical date was not intact was excluded in our study.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Non-HH group Dietary iodine intake restriction Group (participants) without pre-gestational history of undergoing hysterosalpingography (HSG) HH group Dietary iodine intake restriction Group (participants) with pre-gestational history of undergoing hysterosalpingography (HSG) using an oil-soluble iodinated contrast medium
- Primary Outcome Measures
Name Time Method composite neonatal outcome 6-9 months post identification of maternal iodine excess Apgar scores, birth weight of the neonates,and prevalence of thyroid dysfunction in neonates
prevalence of adverse pregnancy outcome 6-9 months post identification of maternal iodine excess prevalence of stillbirth, abortion and other adverse pregnancy outcome
- Secondary Outcome Measures
Name Time Method prevalence of neonatal iodine excess within 1 week after birth urinary iodine concentration will be examined for all neonates born to women with iodine excess in pregnancy, and prevalence of neonatal urinary iodine concentration ≥ 200μg/L will be summarized.
prevalence of maternal thyroid dysfunction in pregnancy through study completion, about 6-9 months post identification of maternal iodine excess Laboratory reference ranges of TSH during pregnancy were 0.1\~2.5 mIU/L for the first trimester, 0.2\~3.0 mIU/L for the second trimester and 0.3\~3.0 mIU/L for the third trimester.Prevalence of TSH elevation during pregnancy will be summarized.