Determination of the iodine status in pregnant women in the Netherlands. Are current iodine intake recommendations still adequate?
Recruiting
- Conditions
- tekort aan micronutrienten tijdens de zwangerschap (in dit geval jodium)iodine deficiencyiodine intake
- Registration Number
- NL-OMON52954
- Lead Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 96
Inclusion Criteria
- Female
- 18-45y old
- before 16 weeks of pregnancy
- Pregnant of singleton
Exclusion Criteria
- thyroid-disease or any other metabolic disease
- twin-pregnancy
- kidney disease
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main outcome is the median urinary iodine excretion (µg/d) in pregnant<br /><br>women in the Netherlands in relation to serum Tg (µg/l). </p><br>
- Secondary Outcome Measures
Name Time Method <p>• Thyroglobulin and thyroglobulin antibody concentrations in blood serum<br /><br>• Creatinin concentration in urine<br /><br>• Urinary volume<br /><br>• Smoking status (smoking is interfering with iodine metabolism)<br /><br>• Vegan/Vegetarian y/n (soy is competitive for iodine on thyroid)<br /><br>• Nutritional intake specifically related to iodine intake (questionnaire)<br /><br>• Intake other relevant micronutrients for pregnant women from supplement use<br /><br>(vitamin D, folate, calcium; questionnaire)<br /><br>Other study parameters/endpoints:<br /><br>• Pre-pregnancy body weight (self-reported)<br /><br>• Height (self-reported)<br /><br>• BMI<br /><br>• Educational level<br /><br>• Age<br /><br>• Ethnicity<br /><br>• Parity</p><br>