Is long-term use of proton pump inhibitors associated with vitamin B12 deficiency in elderly individuals?
Completed
- Conditions
- cobalamin deficiency10047635low vitamin B12 serum levels
- Registration Number
- NL-OMON29864
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 220
Inclusion Criteria
Individuals of 65 years and older that have had at least 810 Defined Daily Doses (DDD) of proton pump inhibitors in the last three years and live with their partner.
Exclusion Criteria
A couple will be excluded from study participation if the general practitioner indicates that one of the following characteristics apply to the user of proton pump inhibitors or partner:
-vitamin B12 supplementation
-folic acid supplementation
-use of H2-blockers
-use of antacids
-known chronic alcohol abuse
-cognitive impairment
A couple will also be excluded when the partner uses proton pump inhibitors.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>We will compare serum vitamin B12, folic acid and homocysteine between the two<br /><br>study groups.<br /><br>Results will be adjusted for possible differences in nutritional behavior and<br /><br>status, health status, use of vitamin supplements and helicobacter pylori<br /><br>status. </p><br>
- Secondary Outcome Measures
Name Time Method <p>We will compare hemoglobin levels and mean corpuscular volumebetween the two<br /><br>study groups. </p><br>