Interleukin 38 as a Biomarker for Metabolic Syndrome in Psoriatic Patients

• Conditions: Psoriasis
• Interventions: Diagnostic Test: measure plasma level of interleukin 38 by ELISA kit

• Registration Number: NCT05076812
• Lead Sponsor: Sohag University

Brief Summary

case control study to compare level of interleukin 38 in patients with psoriasis and patients with metabolic syndrome with healthy control subjects

Detailed Description

this case control study will measure plasma level of interleukin 38 in 4 groups of 24 subject, group one will have psoriatic patients, group 2 will have psoriatic patients with metabolic syndrome, group three will have patients with metabolic syndrome only, and group 4 will have healthy control subjects.

Study Timeline

• Study First Submitted: 2021-09-20
• Study First Submitted QC: 2021-09-29
• Status Verified: 2021-10
• Study Start: 2021-10
• Study First Posted: 2021-10-13
• Last Update Submitted: 2021-10-13
• Last Update Posted: 2021-10-21
• Primary Completion: 2022-05
• Study Completion: 2022-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 96

Inclusion Criteria

• specific to each group

Exclusion Criteria

• Patient refusal. Age <18 years Pregnancy Lactation smoking Infections. Patients with other inflammatory skin disorders use of antioxidant and anti-inflammatory drugs patients on treatment for psoriasis

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group 1 (Psoriasis only)	measure plasma level of interleukin 38 by ELISA kit	contains 24 psoriatic patients, Psoriasis Area Severity Index will be measured, also waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile and finally: plasma level of interleukin 38
Group 2 (Psoriasis and metabolic syndrome)	measure plasma level of interleukin 38 by ELISA kit	contains 24 psoriatic patients with metabolic syndrome. Psoriasis Area Severity Index will be measured metabolic syndrome is diagnosed after measuring waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile finally: plasma level of interleukin 38
Group 3 (Metabolic syndrome only)	measure plasma level of interleukin 38 by ELISA kit	contains 24 patients with metabolic syndrome only. full dermatological examination to exclude psoriasis and other inflammatory skin disorders metabolic syndrome is diagnosed after measuring waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile finally: plasma level of interleukin 38
Group 4 (Healthy Controls)	measure plasma level of interleukin 38 by ELISA kit	contains 24 healthy control subjects full dermatological examination to exclude psoriasis and other inflammatory skin disorders metabolic syndrome is excluded after measuring waist circumference, body mass index, blood pressure, fasting blood glucose and fasting lipid profile finally: plasma level of interleukin 38

Primary Outcome Measures

Name	Time	Method
measure plasma level of interleukin 38 in all groups	through study completion an average of 18 months	level of interleukin 38 will be measured and compared in all groups to asses the relationship between this interleukin and metabolic syndrome in psoriatic patients