The Impact of Genetic and Environmental Factors on the Progression of Chronic Pancreatitis：An Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 798
- 主要终点
- the Number of Patients Developing Pancreatic Insufficiency
研究概览
简要总结
To explore the impact on genetic and environmental factors for clinical manifestation, and the progression of chronic pancreatitis, including development of pancreatic insufficiency and other complications.
详细描述
The present study was an observational study aimed to explore the impact of genetic factors (rare pathogenic variants of CP) and environmental factors(smoking and alcohol assumption) on the clinical manifestation and progression of CP. The observation items included the pain patterns, incidence of complications of CP, pancreatic cancer and death.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients with a diagnosis of chronic pancreatitis
- •agree to join the study and provide informed consent
排除标准
- •autoimmune pancreatitis
- •pancreatic cancer diagnosed within 2 years after the diagnosis of chronic pancreatitis
- •the follow-up time less than 2 years
- •patients presenting with diabetes and/or steatorrhea at onset of CP.
结局指标
主要结局
the Number of Patients Developing Pancreatic Insufficiency
时间窗: 10 years
The primary endpoint was the number of patients developing pancreatic insufficiency, categorised as 1) diabetes and steatorrhea, 2) diabetes only, or 3) steatorrhea only.
次要结局
- Death(20 years)
研究者
Zhuan Liao
Principal Investigator
Changhai Hospital