The Impact of Genetic and Environmental Factors on the Progression of Chronic Pancreatitis：An Observational Study
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Pancreatitis
- Sponsor
- Changhai Hospital
- Enrollment
- 798
- Primary Endpoint
- the Number of Patients Developing Pancreatic Insufficiency
- Status
- Active, not recruiting
- Last Updated
- 4 years ago
Overview
Brief Summary
To explore the impact on genetic and environmental factors for clinical manifestation, and the progression of chronic pancreatitis, including development of pancreatic insufficiency and other complications.
Detailed Description
The present study was an observational study aimed to explore the impact of genetic factors (rare pathogenic variants of CP) and environmental factors(smoking and alcohol assumption) on the clinical manifestation and progression of CP. The observation items included the pain patterns, incidence of complications of CP, pancreatic cancer and death.
Investigators
Zhuan Liao
Principal Investigator
Changhai Hospital
Eligibility Criteria
Inclusion Criteria
- •patients with a diagnosis of chronic pancreatitis
- •agree to join the study and provide informed consent
Exclusion Criteria
- •autoimmune pancreatitis
- •pancreatic cancer diagnosed within 2 years after the diagnosis of chronic pancreatitis
- •the follow-up time less than 2 years
- •patients presenting with diabetes and/or steatorrhea at onset of CP.
Outcomes
Primary Outcomes
the Number of Patients Developing Pancreatic Insufficiency
Time Frame: 10 years
The primary endpoint was the number of patients developing pancreatic insufficiency, categorised as 1) diabetes and steatorrhea, 2) diabetes only, or 3) steatorrhea only.
Secondary Outcomes
- Death(20 years)