A clinical trial to study the effect of amino acid infusion on body temperature in patients undergoing knee joint replacement surgery in cold operating room environment.
Not Applicable
Completed
- Registration Number
- CTRI/2009/091/000972
- Lead Sponsor
- SANT PARMANAND HOSPITA
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 160
Inclusion Criteria
Patients of either sex, of physical status ASA Grade I/II, in the age group of 60 ? 80 years admitted for elective bilateral total knee replacement surgery will be recruited for the study.
Exclusion Criteria
1.Bleeding disorders
2.Spinal deformity/infection
3.Extremes of weight (BMI >30 or BMI<20)
4.Core temperature > 37˚C
5.On vasodilators or medications likely to alter thermoregulation .
6.Clinical hypothyroidism or hyperthyroidism
7.Dysautonomia
8.Known allergy to drugs used in the study
9.Requiring blood transfusion intraoperatively
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method In patients undergoing bilateral total knee replacement under combined spinal-epidural anaesthesia:<br><br>1.To evaluate the surface and core temperature changes<br>2.To compare the surface and core temperature changes<br>3.To evaluate the effect of amino acid infusion on surface and core temperatures<br>4.To compare the change in surface and core temperatures in patients receiving amino acid infusion.<br>Timepoint: O.5 degrees difference in fall in temperature in patients receiving amino acid infusion
- Secondary Outcome Measures
Name Time Method Decreased mortality and morbidityTimepoint: