Functional MRI Evaluation in Pyeloureteral Junction Syndrome in Children

• Conditions: Stricture of Pelviureteric Juncture

• Registration Number: NCT05498532
• Lead Sponsor: Central Hospital, Nancy, France

Brief Summary

Pyelo-ureteral junction syndrome is the most common urological abnormality in children.

Functional MRI has been evaluated several times, and had shown good correlation with scintigraphy, but tends to over estimate results. Moreover, those studies included a small number of cases. Its sensitivity to detect crossing polar vessel is limited.

We aimed to evaluate, in patients between 0 and 1 year old, the correlation between MRI and scintigraphy differential renal function.

Our secondary objectives are : evaluation of MRI performances to detect polar vessel ; comparison of surgery times depending of MRI only realisation or MRI and scintigraphy realisation.

Detailed Description

Not available

Study Timeline

• Status Verified: 2022-08
• Study First Submitted: 2022-08-10
• Study First Submitted QC: 2022-08-10
• Last Update Submitted: 2022-08-10
• Study First Posted: 2022-08-12
• Last Update Posted: 2022-08-12
• Study Start: 2022-09-01
• Primary Completion: 2022-09-15
• Study Completion: 2022-12-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 270

Inclusion Criteria

• children between 0 and 17 years old
• followed for pyelo-ureteral junction syndrome

Exclusion Criteria

• none

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MRI and scintigraphy differential renal function correlation	from january 2007 to december 2021	Evaluation of differential renal function between MRI and scintigraphy in children between 0 and 1 year old ; Pearson correlation coefficient

Secondary Outcome Measures

Name	Time	Method
performance of MRI in detecting polar vessel	from january 2007 to december 2021	Polar vessel : comparison between MRI results and operatory observation, sensitivity et specificity analysis
MRI and scintigraphy differential renal function correlation in operated patient	from january 2007 to december 2021	Evaluation of differential renal function between MRI and scintigraphy in children operated for PUJS; Pearson correlation coefficient
Time difference in patient operated for PUJS depending on MRI realisation ou MRI and scintigraphy realisation	from january 2007 to december 2021	Comparison between the mean time between MRI and surgery, and mean time between MRI, scintigraphy and surgery

Trial Locations

Locations (1)

CHRU Nancy; 🇫🇷 Vandœuvre-lès-Nancy, Lorraine, France