Study to Compare the Heparin Induced Thrombocytopenia Rates Associated With Heparin and Low Molecular Weight Heparin Usage as Well as Evaluate the Economic and Long-Term Clinical Burden of Heparin Induced Thrombocytopenia.

The goal of this research is to investigate the outcomes and pharmacoeconomics of patients diagnosed with heparin induced thrombocytopenia (HIT).

Background:

Heparin induced thrombocytopenia (HIT) is a complication of heparin therapy receiving wide-scale awareness, increasing detection, and concern. Data from controlled studies demonstrate a lower incidence of HIT with low molecular-weight heparin (LMWH) when compared to unfractionated heparin (UFH) However, registry data comparing the incidence of HIT in patients receiving LWMH vs. UFH are scarce. We will define the incidence of HIT in patients receiving LWMH vs. UFH in the "real world" setting at Brigham and Women's Hospital. We will evaluate the associated clinical and economic implications.

Our Objectives are:

1. Compare the HIT rates associated with heparin and LMWH usage: