Medical Education for Sepsis Source Control and Antibiotics

Not Applicable

• Conditions: Severe SepsisSeptic Shock; A41; Other sepsis

• Registration Number: DRKS00000621
• Lead Sponsor: Jena University HospitalCenter for Sepsis Control & Care

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-11-25
• Study Completion: 2013-07-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 4138

Inclusion Criteria

1. For the hospitals (cluster):
- Involved in the primary care of patients with severe sepsis/septic shock
- Willing to participate in a guideline implementation process

2. For the patients:
- New onset of suspicion of severe sepsis or septic shock in the following settings:
a. Prehospital
b. Emergency department
c. Operating theatre
d. Regular ward
e. Intensive care unit (ICU)/Intermediate Care Unit (IMC)

Exclusion Criteria

1. For the hospitals (cluster):

- No intensive care unit available
- no acute care for patients with severe sepsis and septic shock

2. For the patients:
- Start of sepsis therapy in a non-study site
- Patients not admitted to the ICU/IMC
- No commitment to full medical support (i.e. DNR)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
28 days all-cause mortality

Secondary Outcome Measures

Name	Time	Method
Fraction of patients with antimicrobial therapy within 1 hour<br>Duration until antimicrobial therapy<br>Duration until focus control<br>Frequency of blood cultures<br>Frequency of adequate antimicrobial therapy<br>ICU and hospital mortality<br>ICU and and hospital length of stay