Effect of the Folic Acid and Vitamin B12 Supplements with Metformin on the Plasma Homocysteine Levels in Women with Polycystic Ovary Syndrome
Phase 2
- Conditions
- Polycystic ovary syndrome.Polycystic ovarian syndrome
- Registration Number
- IRCT201108171760N14
- Lead Sponsor
- Vice Chancellor for Research and Technology, Babol University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 150
Inclusion Criteria
Patients with PCOs aged 17-35 years. Exclusion criteria: Patients with each background of malady (such as, cardiovascular diseases, diabetes, congenital adrenal hyperplasia,…); using of drugs anti-pregnancy, hormonal, anti-overweight and medications known to interfere with folic acid and vitamin B12 metabolism (such as, metotreksat, nitric oxide and Azaribine), history of hypertension, high activity of body, alcoholic, smoker and subjects with > 120 mg/ml serum folic acid and =1000 pg/ml vitamin B12 than normal ranges.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hyperhomocysteinaemia. Timepoint: During the period of six months after treatment. Method of measurement: clinical and laboratory findings.;Hyperinsulinaemia. Timepoint: During the period of six months after treatment. Method of measurement: clinical and laboratory findings.
- Secondary Outcome Measures
Name Time Method Serum folic acid levels. Timepoint: Six months after starting treatment. Method of measurement: laboratory findings.;Serum vitamin B12 levels. Timepoint: Six months after starting treatment. Method of measurement: laboratory findings.;Serum homocysteine(HCY) ??levels. Timepoint: Six months after starting treatment. Method of measurement: laboratory findings.