Effect of Sarcopenia on Clinical Outcome of Total Knee Arthroplasty
- Conditions
- Knee Osteoarthritis
- Interventions
- Procedure: Arm I (Sarcopenia)Procedure: Arm II(Normal)
- Registration Number
- NCT06136039
- Lead Sponsor
- Gangnam Severance Hospital
- Brief Summary
As human life expectancy increases, the prevalence of degenerative osteoarthritis of the knee joints is steadily rising, leading to a significant surge in the frequency of total knee arthroplasty (TKA). However, research on sarcopenia in the population that comprises the primary recipients of these orthopedic joint surgeries has been notably lacking. Since the release of the 2019 Consensus update on sarcopenia by the Asian Walking Group for Sarcopenia (AWGS) in 2020, research on sarcopenia has gained momentum in various domains. Yet, as previously mentioned, the field of orthopedics still lags behind in investigating sarcopenia. Therefore, it is believed that establishing the relationship between sarcopenia and surgical outcomes in the elderly, who are the primary targets of orthopedic joint replacement surgery, could offer insights to further enhance the results of joint replacement surgeries.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- Female
- Target Recruitment
- 150
- A woman aged 60 or older who is undergoing TKA due to degenerative osteoarthritis of the knee joint at the our institution.
- Male
- Under 60 years of age
- Patients with a history of rheumatoid arthritis, traumatic joint disease, and post-infection joint disease
- Patients who cannot undergo tests for muscle weakness diagnosis A. Patients unable to walk B. Patients unable to stand alone due to conditions like cerebral palsy or brain disorders C. Patients unable to use muscle strength
- Patients considered inappropriate for recruitment in this study based on the judgment of the research team.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Sarcopenia Arm I (Sarcopenia) Patients were categorized into preoperative sarcopenia Sarcopenia Arm II(Normal) Patients were categorized into preoperative sarcopenia
- Primary Outcome Measures
Name Time Method ASM 6, 12months after surgery Appendicular Skeletal Muscle Mass was measured through Bioelectrical Impedance Analysis.
gait speed 6, 12months after surgery Gait speed was measured using a dedicated camera equipped with LiDAR sensors.
SPPB 6, 12months after surgery The Short Physical Performance Battery was measured using a dedicated device that included a force plate.
handgrip strength, gait speed, SPPB, ASM) 6, 12months after surgery Handgrip strengths were measured using a handgrip dynamometer before surgery. low muscle mass AND (low physical performance OR low strength) : sarcopenia low muscle mass AND (low physical performance AND low strength) : severe sarcopenia
- Secondary Outcome Measures
Name Time Method EQ-5D 3, 6, and 12months after surgery The EuroQol 5 Dimension (EQ-5D) is a self-report survey that measures quality of life across 5 domains: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression
UCLA score 3, 6, and 12months after surgery The UCLA Activity Scale (UCLA) is a questionnaire assessing physical activity level from 1 (low) to 10 (high) in patients undergoing hip or knee arthroplasty
Knee Society Score 3, 6, and 12months after surgery The original KSS has a "Knee Score" section (7 items) and a "Functional Score" section (3 items). Both sections are scored from 0 to 100 with lower scores being indicative of worse knee conditions and higher scores being indicative of better knee conditions
WOMAC 3, 6, and 12months after surgery Higher scores indicate worse pain, stiffness, and functional limitations. The WOMAC measures five items for pain (score range 0-20), two for stiffness (score range 0-8), and 17 for functional limitation (score range 0-68).
Trial Locations
- Locations (1)
GangnamSeverance Hospital
🇰🇷Seoul, Korea, Republic of