PET-study on the role of the reward system in weight loss after bariatric surgery

Recruiting

Conditions: fatness
Overweight
10003018
10014067
corpulence

Registration Number: NL-OMON51338

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

- Bariatric surgery 24-36 months prior to the study
- Adult (over 18y old)
- Mentally capable to understand the consequences of the procedure and make
his or her own choice without coercion
- Able to undergo PET and MRI, according to the investigator*s assessment
- Able to participate in follow-up
- Written informed consent

Exclusion Criteria

- Presence of a DSM-IV axis 1 disorder
- The use of drugs that bind to dopamine D2/3 receptors, including various
classes of antipsychotics and antidepressants
- History of stroke, brain tumor, Parkinson*s Disease or dementia
- Alcohol or substance abuse in the last 6 months
- Alcohol consumption 24h prior to PET scanning
- Smoking or other forms of nicotine intake 12 hours prior to PET scanning
- Use of anorectic drugs in the last 6 months
- Current pregnancy
- Medication for Diabetes Mellitus
- Claustrophobia
- The presence of implanted metal objects of the type which may concentrate
radiofrequency fields or cause tissue damage from twisting in a magnetic field
(such as certain implanted devices, shrapnel, ocular metal shavings)
- Patients with a bodyweight > 200kg will be excluded to ensure the maximum
load of the camera bed of the PET-scanner (227 kg) is not exceeded.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Pre- and post-eating differences in dopamine D2 receptor availability as<br /><br>indexed by the [11C]-raclopride binding potential in the brain*s reward system<br /><br>between subjects who underwent successful vs unsuccessful bariatric surgery.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The correlation between questionnaires on eating habits (EDE-Q, REO, YFAS) and<br /><br>quality of life (OBESI-Q) in patients who had successful vs unsuccessful BS and<br /><br>[11C]-raclopride binding potential.<br /><br>The relation between fasting or fed (gut) hormone concentrations and dopamine<br /><br>D2 receptor availability in the reward system .</p><br>