RBR-8xdc8yz尚未招募2 期
Randomized clinical trial to evaluate the safety and pharmacodynamics of the PARP inhibitor Olaparib in sepsis - PARP Poly [ADP-ribose] polymerase
Escola Paulista de Medicina, Universidade Federal de São Paulo0 个研究点开始时间: 2022年12月30日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Intervention
入排标准
- 年龄范围
- 18Y 至 60Y（—）
- 性别
- Male
入选标准
- •Male patients diagnosed with septic shock for less than 24 hours; signing of free and informed consent form
排除标准
- •Female patients (women) because women's hormones can alter the effects of olaparib; patients unable to use medication by mouth or by tube; patients with AIDS; patients using immunosuppressive therapy, that is, which compromises the body's defenses; patients using corticosteroids; patients with cancer or undergoing chemotherapy; chemotherapy performed up to 30 days; patients who had cardiac arrest; patients with recent acute infarction or problems with the coronary artery, the artery that supplies the heart; liver disease, such as liver cirrhosis; very severe patients, with the prospect of death within 24 hours; palliative or end-of-life care; patients using treatments that may have their effects altered or alter the effects of olaparib (examples: itraconazole, fluconazole, verapamil, rifampicin, phenytoin, carbamazepine, phenobarbital and modafinil; Saint John's herb)
研究者
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