Chronic pain after breast cancer surgery.
Recruiting
- Conditions
- Chronic pain, breast cancer, surgery, sensitisation, mechanism, cox-2, quantitative sensory testing
- Registration Number
- NL-OMON20830
- Lead Sponsor
- 03-06-2009 update: UMC St. Radboud and Bernhoven Hospital
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 110
Inclusion Criteria
110 patients (n=55 per group) due to undergo elective first surgery for malignancy of the breast at UMC St. Radboud or Bernhoven Ziekenhuis in Oss.
Exclusion Criteria
1. Previous breast surgery;
2. Any type of chronic pain syndrome;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method europlasticity, e.g. central sensitisation as demonstrated by quantitative sensory testing, at one month after surgery.<br>
- Secondary Outcome Measures
Name Time Method 1. Neuroplasticity at other time points after surgery;<br /><br>2. Acute and chronic clinical pain measures (pain scores, analgesic consumption, pain questionnaires);<br /><br>3. Other pain outcome measures (incidence of phantom pain, pain maps, analgesia complications);<br /><br>4. Surgical outcome measures (complications);<br /><br>5. Patient satisfaction and well-being (including nausea and vomiting, opioids symptom distress score SDS).<br>