Comparison between the efficacy of intravenous dexmedetomidine vs intravenous lignocaine on post operative analgesia in patients undergoing laparoscopic cholecystectomy
Overview
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Dr Manchala Jyothi Sai Reddy
- Enrollment
- 86
- Locations
- 1
- Primary Endpoint
- 1) Duration of analgesia
Overview
Brief Summary
This is a prospective observational study to compare intraoperative hemodynamic stability and postoperative analgesia using Intravenous lignocaine vs intravenous dexmedetomidine in patients undergoing laparoscopic cholecystectomy. The study is planned to be conducted at a tertiary hospital in Dakshina Kannada. The study will be carried out on patients aged 18 to 65 years of ASA grade I and II undergoing laparoscopic cholecystectomy. The study has already cleared the institutional ethics committee approval.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18.00 Year(s) to 65.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Patients aged 18 to 65 years of either sex with the American Society of Anesthesiologists physical status classes 1 and 2 undergoing elective laparoscopic cholecystectomy surgery.
Exclusion Criteria
- •Patients unwilling to participate in the study.
- •Patients with BMI more than 35 kgm2 3)History of hypersensitivity to the drugs 4)Parturient 5)Chronic use of opioids or opioid addiction, steroids.
- •Inability to comprehend postoperatively for the pain assessment scale or neuropsychiatric disorders.
Outcomes
Primary Outcomes
1) Duration of analgesia
Time Frame: Intraoperative assessment done at Baseline, After boluses of study drugs, Immediately after ETI, 5min, 15min, 30min, 45m, 1h, 1h15m, 1h30m, 1h45m, 2h, until the pneumoperitoneum is released. | Postoperatively assessed at 1hr, 4hr, 8hr, 12hr, and upto 24 hours
2) VAS score
Time Frame: Intraoperative assessment done at Baseline, After boluses of study drugs, Immediately after ETI, 5min, 15min, 30min, 45m, 1h, 1h15m, 1h30m, 1h45m, 2h, until the pneumoperitoneum is released. | Postoperatively assessed at 1hr, 4hr, 8hr, 12hr, and upto 24 hours
Secondary Outcomes
- 1) Intraoperative Hemodynamic parameters at baseline, after boluses of drugs administration, immediately after intubation, 5min & every 15min until the end of the procedure.(2) Side effects like nausea, vomiting & sore throat.)
Investigators
Manchala Jyothi Sai Reddy
Kasturba Medical College, Mangalore