Macular, papillary and peripapillary vessel density measured using Optical Coherence Tomography-Angiography in patients with Cytomegalovirus-positive Posner-Schlossman Syndrome

• Conditions: H40.4; Glaucoma secondary to eye inflammation

• Registration Number: DRKS00028266
• Lead Sponsor: Charité Campus Virchow-Klinikum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2021-12-22
• Study Start: 2022-03-02
• Results First Posted: 2023-07-22
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

(1) proof of Cytomegalovirus-infection in an aqueous humor sample, (2) at least one transient episode of unilateral elevated intraocular pressure (IOP) over 21 mmHg, (3) low-grade anterior uveitis, (4) no iris synechia, (5) no or minimal cells in the anterior chamber.

Exclusion Criteria

(1) detection of infection with rubella virus, herpes simplex virus (HSV), or varicella-zoster-virus (VZV) in the aqueous humor samples, (2) refractive errors of the sphere or the cylinder >/= -3.50 dpt, (3) history of retinal disease (diabetic retinopathy, age-related macular degeneration) and (4) amaurosis on the contralateral eye

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
As primary outcome we defined alterations of the vessel area density in different retinal vascular layers, using Optical Coherence Tomography-Angiography.

Secondary Outcome Measures

Name	Time	Method
Secondary outcomes are glaucomatous changes measured by Optical Coherence Tomography, differences in the retinal nerve-fiber-layer thickness, endothelial cell density, mean deviation of the perimetry and cup-disc-ratio.