The Effect of Vitamin C-enriched Collagen Combined With Resistance Training on Muscle-tendon Unit Properties in Middle-aged Men and Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 试验地点
- 2
- 主要终点
- Knee extensor rate of torque development (in Newton metres per second)
研究概览
简要总结
The aim of this clinical trial is to investigate the longitudinal effects of hydrolyzed collagen ingestion combined with resistance training on muscle-tendon unit structure and function in middle-aged males and females.
The main research questions this clinical trial aims to answer are:
- Does resistance training with hydrolyzed collagen ingestion lead to greater changes in tendon properties than resistance training alone in middle-aged health men and women?
- Does resistance training with hydrolyzed collagen ingestion lead to greater changes in muscle size than resistance training alone?
- Does resistance training with hydrolyzed collagen lead to greater increases in strength and power compared to resistance training alone in middle-aged, healthy men and women?
Participants will be randomly assigned to collagen or placebo groups. Participants will perform 24 sessions of high intensity resistance training across 12-weeks. Alongside each training session, participants will consume a beverage containing hydrolyzed collagen or maltodextrin, with both beverages containing vitamin C.
Researchers will compare the collagen and placebo groups to see if there would be beneficial effects on changes in muscle and tendon that are greater than resistance training alone. To achieve this, an dynamometry will be used to assess lower limb strength and ultrasound will be used to measure the morphological, mechanical, and material properties of the patellar tendon, as well the size and architecture of the vastus lateralis muscle.
详细描述
Healthy, active, middle-aged men and women will ingest a beverage containing 30 g of hydrolyzed collagen with 50 mg of vitamin C or a calorie matched beverage (maltodextrin), also with 50 mg of vitamin C combined with high-volume, high-intensity resistance training for the lower body on 2 - 3 occasions per week for 8-12 weeks.
The aim of this study was to investigate the effect of combining hydrolyzed collagen with resistance training in middle-aged men and women.If supplementation with hydrolyzed collagen leads to a greater change in tendon size, stiffness, and Young's modulus than resistance training alone, this will allow us to recommend this type of intervention to young athletes seeking to improve tendon health and/or athletic performance. This is the first study to investigate the combination of hydrolyzed collage supplementation with resistance training in middle-aged men and women. If supplementation with hydrolyzed leads to greater improvements in tendon size, stiffness, strength and/or power, this will allow us to recommend this type of intervention to middle-aged athletes/trainees seeking to improve tendon health, reduce injury risk, or enhance athletic performance.
The experimental design of both arms will be the same, however Arm 1 will be health, middle-aged male participants and Arm 2 will be health, middle-aged female participants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
盲法说明
Before the intervention commenced, a laboratory technician (independent to the study) made up the dry ingestions all the 30 g doses of hydrolyzed collagen (HC), and calorie matched placebo and stored in sachets. These sachets were labelled as with the participants name. The technician randomly assigned either HC or placebo to participants who were pair matched (Excel 2016, Microsoft, Washington, USA). The groupings and contents of the sachets were unknown to the researcher and the participants, who all remained blinded until data collection and analysis were complete.
入排标准
- 年龄范围
- 35 Years 至 59 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Recreationally active or competing in Masters sport
- •No history of patellar tendon injuries in the past 6 months
- •No history of lower limb musculoskeletal injuries in the past 6 months
- •Non-smokers (including e-cigarettes)
- •Free from cardiovascular and metabolic diseases
排除标准
- •Age < 35 years or > 59 years
- •Being vegan or vegetarian (due to the mammalian source of collagen)
- •Injury history incompatible with lower body resistance training
- •Consumption of nutritional supplementation that purportedly affects muscle-tendon adaptation or recovery (i.e. protein powder, vitamin C, collagen)
- •BMI over 30 kg/m2
结局指标
主要结局
Knee extensor rate of torque development (in Newton metres per second)
时间窗: 8-12 weeks' training and nutrition intervention
Changes in explosive knee extension strength were measured using isometric dynamometry (Biodex System 3, IPRS Mediquipe Limited, Lancashire, UK)
m. vastus lateralis thickness (in millimetres)
时间窗: 8-12 weeks' training and nutrition intervention
Ultrasonography was used to determine changes in muscle thicknessprotocols
Barbell back squat 10-repetition maximum (in kilograms)
时间窗: 8-12 weeks' training and nutrition intervention
Changes in dynamic lower body strength were measured using the maximum load during 10 repetitions of the barbell back squat exercise with standardised technique
m. vastus lateralis fascicle pennation angle (in degrees)
时间窗: 8-12 weeks' training and nutrition intervention
Ultrasonography was used to determine the pennation angle of fascicles as they insert into the aponeurosis
Patellar tendon stiffness (in Newtons per millimetre)
时间窗: 8-12 weeks' training and nutrition intervention
Synchronized ultrasonography, dynamometry, and surface electromyography were used to determine changes in patellar tendon stiffness
Knee extensor maximal isometric torque (in Newton metres)
时间窗: 8-12 weeks' training and nutrition intervention
Changes in maximal knee extension strength were measured using isometric dynamometry (Biodex System 3, IPRS Mediquipe Limited, Lancashire, UK)
20-metre sprint time (in seconds)
时间窗: 8-12 weeks' training and nutrition intervention
Double photocell timing gates (Witty System, Microgate SRL, Bolzano, Italy) were used to measure changes in time taken to cover 20-metres during an all out sprint on a standardised surface
Patellar tendon cross sectional area (in squared millimetres) at 3 regions along the tendon length
时间窗: 8-12 weeks' training and nutrition intervention
Ultrasonography was used to determine changes in tendon cross sectional area at 25, 50, and 75 % of tendon length
Bilateral vertical countermovement jump height (in centimetres)
时间窗: 8-12 weeks' training and nutrition intervention
Changes in jump height were estimated by use of the Optojump system (Microgate, Bolzano, Italy) and force plates (Force Decks Dual Force Plate System, VALD, Charlotte NC, USA).
Bilateral horizontal broad jump distance (in centimetres)
时间窗: 8-12 weeks' training and nutrition intervention
Changes in maximal horizontal displacement were measured as the maximum distance covered during a broad jump on standardised surface without footwear
Lower limb maximal isometric force (in Newtons)
时间窗: 8-12 weeks' training and nutrition intervention
Force plates (Force Decks Dual Force Plate System, VALD, Charlotte NC, USA) were used to measure changes in maximal multi-joint isometric strength during the mid-thigh pull exercise
Lower limb isometric rate of force development (in Newtons per second)
时间窗: 8-12 weeks' training and nutrition intervention
Force plates (Force Decks Dual Force Plate System, VALD, Charlotte NC, USA) were used to measure changes in explosive multi-joint isometric strength during the mid-thigh pull exercise
次要结局
未报告次要终点