Characteristics of Hoffa Adipose Tissue and Intramuscular Adipose Tissue in the Quadriceps Muscle

Recruiting

• Conditions: Osteo Arthritis Knee
• Interventions: Other: BIOPSY

• Registration Number: NCT05955976
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

Over the last few years, it has been suggested that Knee Ostheoarthritis (KOA) incidence and progression could potentially be related to skeletal muscle characteristics. In particular, weakness of the quadriceps muscle would be a key determinant of KOA. However the mechanisms underpinning the influence of skeletal muscle in the pathophysiology of ostheoarthritis (OA) are poorly understood.

Crosstalk between skeletal muscle and structures around and in the joint is of interest. In physical deconditioning and aging, it has been reported that skeletal muscle can be replaced by adipose tissue. Several factors involved in the development of OA but also of adipose tissue may be involved in these muscular changes. Of interest, in patients with KOA, quadriceps weakness is an ubiquitous clinical finding. Infiltration of adipose tissue in skeletal muscle has been shown to affect muscle strength and mobility and be linked to cartilage volume loss and the occurrence/progression of KOA.

The main objective of this study is to compare the characteristics of the Hoffa tissus and the intamuscular fat (IMF) tissus in the quadriceps muscle in patients with gonarthrosis requiring total knee prosthesis.

This is a single-centre study based on a collection of surgical waste and is categorized as Research Not Involving Human subjects.

Detailed Description

Not available

Study Timeline

• Status Verified: 2023-07
• Study First Submitted: 2023-07-13
• Study First Submitted QC: 2023-07-13
• Study Start: 2023-07-20
• Study First Posted: 2023-07-21
• Last Update Submitted: 2023-07-24
• Last Update Posted: 2023-07-25
• Primary Completion: 2023-09-20
• Study Completion: 2024-03-20

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Adult patient, aged between 40 and 85 years
• Patient having a confirmed diagnosis of knee ostheoarthritis
• Patient undergoing a surgery for a total knee prosthesis for knee ostheoarthritis

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients suffering of knee ostheoarthritis undergoing a surgery for a total knee prosthesis.	BIOPSY	-

Primary Outcome Measures

Name	Time	Method
Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps):fibrotic tissue	4 months	rate mesured in %
Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps): adipose tissue size differences	4 months	size mesured in mm
Comparison between Hoffa tissue and intramuscular fat tissue (quadriceps): lipid levels	4 months	level mesured in %

Trial Locations

Locations (1)

Nice University Hospital; 🇫🇷 Nice, France