Impact of Protamine Dose Reduction on Platelet Aggregation After Extracorporeal Circulation for Minimally Invasive Aortic Valve Replacement Surgery

Not Applicable

Not yet recruiting

• Conditions: Protamine Dose; Protamine Adverse Reaction
• Interventions: Drug: Low dose protamine

• Registration Number: NCT06254404
• Lead Sponsor: University of Liege

Brief Summary

Determining the minimum effective dose of protamine after extracorporeal circulation for mini-sternotomy aortic valve replacement surgery.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-02
• Study First Submitted: 2024-02-02
• Study First Submitted QC: 2024-02-02
• Last Update Submitted: 2024-02-02
• Study First Posted: 2024-02-12
• Last Update Posted: 2024-02-12
• Study Start: 2024-03-15
• Primary Completion: 2024-10-01
• Study Completion: 2024-10-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Mini-sternotomy aortic valve replacement surgery
• Major patients

Exclusion Criteria

• Hypersensitivity to protamine
• Coagulation Abnormalities
• Heparin allergy
• Pregnant women
• Jehovah's Witnesses

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Low dose of Protamine	Low dose protamine	-
Normal dose of protamine	Low dose protamine	-

Primary Outcome Measures

Name	Time	Method
Minimum effective dose of protamine after extracorporeal circulation. A bottom-up and top-down method will define CP 50.	24 hours