Appropriate protamine dosage for post cardiopulmonary bypass patient with borderline activated clotting time

Phase 2

Recruiting

• Conditions: elective cardiac surgery patients using cardiopulmonary bypassage between 18- 80 years oldno bleeding tendency preoperative (abnormal platelet, aPTT, PT, INR)no preoperative anticoagulant drugs; cardiac surgery; cardiopulmonary bypass

• Registration Number: TCTR20190308003
• Lead Sponsor: Faculty of Medicine Ramathibodi hospital Mahidol University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-08
• Study Completion: 2020-03-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

1.elective cardiac surgery patients using cardiopulmonary bypass
2.no bleeding tendency preoperative (abnormal platelet, aPTT, PT, INR)
3. no preoperative anticoagulant drugs

Exclusion Criteria

1.Suspected heparin resistance, heparin induced thrombocytopenia
2.Hypothermia patient (Core temperature below 36 Celcius)
3.Cardiopulmonary bypass time more than 2 hours
activated clotting time (ACT) value after 1st routine protamine dose below 120 seconds or more than 160 seconds or more than baseline value 15%
4.Deny or request for exclude from study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
post operative bleeding 6 hours after operative drain volume

Secondary Outcome Measures

Name	Time	Method
laboratory investigation outcome after protamine second dose ACT, activated partial thromboplastin time